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. 1991 Apr 11;19(7):1695–1698. doi: 10.1093/nar/19.7.1695

Interactions of nucleic acids with distamycins. Binding of Dst-3 to d(CGTTTAAACG)2 and d(CGTACGTACG)2.

M L Capobianco 1, F P Colonna 1, A Forni 1, A Garbesi 1, S Iotti 1, I Moretti 1, B Samori 1, L Tondelli 1
PMCID: PMC333934  PMID: 2027777

Abstract

The binding between Distamycin 3 and the palindromic duplexes d(CGTTTAAACG)2 and d(CGTACGTACG)2 was investigated by two independent techniques: UV-Vis absorption in the Job's plot approach and Induced Circular Dichroism. Both decamers bind two molecules of peptide per duplex, with close overall affinities. This result indicates that a row of six A:T base pairs can accommodate two molecules of drug and that the minimal binding site of Distamycin 3 can consist of just two A:T base pairs.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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