Table 3.

Independent predictors of higher circulating osteoprotegerin (tertile 3) at baseline

Variable	OR (95% CI)	p Value
Age (>75 years)	2.18 (1.76 to 2.72)	<0.001
Creatinine clearance <60 ml/min	1.80 (1.46 to 2.23)	<0.001
Baseline BNP (>80 ng/l)	1.60 (1.36 to 1.89)	<0.001
History of hypercholesterolaemia (yes)	0.70 (0.59 to 0.82)	<0.001
History of diabetes (yes)	2.04 (1.73 to 2.41)	<0.001
History of heart failure (yes)	1.46 (1.19 to 1.80)	<0.001
Gender (males)	0.76 (0.64 to 0.89)	0.001
Region: Eastern Europe (referent North America)	0.74 (0.59 to 0.93)	0.010
Region: Western Europe (referent North America)	1.33 (1.08 to 1.63)	0.006
Index event NSTEMI (referent UA)	1.34 (1.10 to 1.62)	0.003
Family history of CAD	0.83 (0.70 to 0.97)	0.021
TnI ultra positive (≥40 ng/l)	1.24 (1.01 to 1.53)	0.042

BNP, B type natriuretic peptide; CAD, coronary artery disease; NSTEMI, non-ST elevation myocardial infarction; TnI, troponin I; UA, unstable angina.