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. 1992 Sep 25;20(18):4711–4716. doi: 10.1093/nar/20.18.4711

Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability.

K Augustyns 1, F Vandendriessche 1, A Van Aerschot 1, R Busson 1, C Urbanke 1, P Herdewijn 1
PMCID: PMC334221  PMID: 1329028

Abstract

Oligonucleotides containing 1-(2,4-dideoxy-beta-D-erythro-hexopyranosyl)thymine (2) and 1-(3,4-dideoxy-beta-D-erythro-hexopyranosyl)thymine (3) were synthesized on a solid support using the phosphoramidite approach. The properties of these oligonucleotides were compared with the earlier reported characteristics of oligonucleotides containing 1-(2,3-dideoxy-beta-D-erythro-hexopyranosyl) thymine (1). The order in enzymatic stability of end-substituted oligonucleotides is 3 greater than 1 much greater than 2. The hybridization properties of the modified oligonucleotides are in reverse order: 2 much greater than 1 greater than 3.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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