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. Author manuscript; available in PMC: 2013 Aug 1.
Published in final edited form as: Hippocampus. 2012 Jan 23;22(8):1681–1690. doi: 10.1002/hipo.22003

Figure 3.

Figure 3

Inhibition of nAChRs in the ventral hippocampus during systemic nicotine administration results in an enhancement of contextual fear conditioning. A) Administration of DHβE (18 ug per side) or MLA (27 ug per side) into the ventral hippocampus during systemic nicotine administration at training results in the enhancement of contextual fear conditioning and no effect on baseline freezing. B) Infusions of DHβE (18 ug per side) into the ventral hippocampus at training results in an enhancement of contextual fear conditioning whereas infusion of DHβE prior to testing only results in a deficit. DHβE infusions did not alter baseline freezing. C) Infusion of MLA (27 ug per side) into the ventral hippocampus at training only or testing only did not alter contextual fear conditioning or baseline freezing. * - p < 0.05 compared to saline infused/injected mice. Data represents mean + SEM.