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. 1989 Oct 11;17(19):7771–7778. doi: 10.1093/nar/17.19.7771

A cis-acting transcription element of the c-myc gene can assume an H-DNA conformation.

A J Kinniburgh 1
PMCID: PMC334884  PMID: 2678005

Abstract

I have used chemical probes and an oligonucleotide-association assay to determine the structure of a nuclease-sensitive, c-myc DNA region. I find that this DNA region can form a triplex-single stranded conformer in vitro--the H-DNA conformer. This DNA region has been shown previously to be a positive, cis-acting transcription element of the c-myc gene and to bind nuclear factors, including a base-paired ribonucleoprotein. Therefore, H-DNA may be a functionally important in vivo topoisomer where the H-DNA and B-DNA conformers have different transcriptional activities.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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