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. 1967 Mar;57(3):759–766. doi: 10.1073/pnas.57.3.759

ROLE OF GUANOSINE 5′-TRIPHOSPHATE IN THE INITIATION OF PEPTIDE SYNTHESIS, I. SYNTHESIS OF FORMYLMETHIONYL-PUROMYCIN*

J W B Hershey 1, R E Thach 1
PMCID: PMC335573  PMID: 16591528

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bretscher M. S., Marcker K. A. Polypeptidyl-sigma-ribonucleic acid and amino-acyl-sigma-ribonucleic acid binding sites on ribosomes. Nature. 1966 Jul 23;211(5047):380–384. doi: 10.1038/211380a0. [DOI] [PubMed] [Google Scholar]
  2. Capecchi M. R., Gussin G. N. Suppression in vitro: Identification of a Serine-sRNA as a "Nonsense" Suppressor. Science. 1965 Jul 23;149(3682):417–422. doi: 10.1126/science.149.3682.417. [DOI] [PubMed] [Google Scholar]
  3. Capecchi M. R. Initiation of E. coli proteins. Proc Natl Acad Sci U S A. 1966 Jun;55(6):1517–1524. doi: 10.1073/pnas.55.6.1517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Clark B. F., Marcker K. A. The role of N-formyl-methionyl-sRNA in protein biosynthesis. J Mol Biol. 1966 Jun;17(2):394–406. doi: 10.1016/s0022-2836(66)80150-x. [DOI] [PubMed] [Google Scholar]
  5. HOLLEY R. W., APGAR J., DOCTOR B. P., FARROW J., MARINI M. A., MERRILL S. H. A simplified procedure for the preparation of tyrosine and valine-acceptor fractions of yeast "soluble ribonucleic acid". J Biol Chem. 1961 Jan;236:200–202. [PubMed] [Google Scholar]
  6. Hershey J. W., Monro R. E. A competitive inhibitor of the GTP reaction in protein synthesis. J Mol Biol. 1966 Jun;18(1):68–76. doi: 10.1016/s0022-2836(66)80077-3. [DOI] [PubMed] [Google Scholar]
  7. Kolakofsky D., Nakamoto T. The initiation of viral protein synthesis in e. Coli extracts. Proc Natl Acad Sci U S A. 1966 Dec;56(6):1786–1793. doi: 10.1073/pnas.56.6.1786. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Leder P., Bursztyn H. Initiation of protein synthesis II. A convenient assay for the ribosome-dependent synthesis of N-formyl-C14-methionylpuromycin. Biochem Biophys Res Commun. 1966 Oct 20;25(2):233–238. doi: 10.1016/0006-291x(66)90586-9. [DOI] [PubMed] [Google Scholar]
  9. NIRENBERG M., LEDER P. RNA CODEWORDS AND PROTEIN SYNTHESIS. THE EFFECT OF TRINUCLEOTIDES UPON THE BINDING OF SRNA TO RIBOSOMES. Science. 1964 Sep 25;145(3639):1399–1407. doi: 10.1126/science.145.3639.1399. [DOI] [PubMed] [Google Scholar]
  10. Nishizuka Y., Lipmann F. The interrelationship between guanosine triphosphatase and amino acid polymerization. Arch Biochem Biophys. 1966 Sep 26;116(1):344–351. doi: 10.1016/0003-9861(66)90040-3. [DOI] [PubMed] [Google Scholar]
  11. Salas M., Hille M. B., Last J. A., Wahba A. J., Ochoa S. Translation of the genetic message, ii. Effect of initiation factors on the binding of formyl-methionyl-trna to ribosomes. Proc Natl Acad Sci U S A. 1967 Feb;57(2):387–394. doi: 10.1073/pnas.57.2.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Seeds N. W., Conway T. W. Reversal by GTP of soluble RNA inhibition of polyphenylalanine synthesis. Biochem Biophys Res Commun. 1966 Apr 19;23(2):111–116. doi: 10.1016/0006-291x(66)90513-4. [DOI] [PubMed] [Google Scholar]
  13. Stanley W. M., Jr, Salas M., Wahba A. J., Ochoa S. Translation of the genetic message: factors involved in the initiation of protein synthesis. Proc Natl Acad Sci U S A. 1966 Jul;56(1):290–295. doi: 10.1073/pnas.56.1.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sundararajan T. A., Thach R. E. Role of the formylmethionine codon AUG in phasing translation of synthetic messenger RNA. J Mol Biol. 1966 Aug;19(1):74–90. doi: 10.1016/s0022-2836(66)80051-7. [DOI] [PubMed] [Google Scholar]
  15. TRAUT R. R., MONRO R. E. THE PUROMYCIN REACTION AND ITS RELATION TO PROTEIN SYNTHESIS. J Mol Biol. 1964 Oct;10:63–72. doi: 10.1016/s0022-2836(64)80028-0. [DOI] [PubMed] [Google Scholar]
  16. Thach R. E., Dewey K. F., Brown J. C., Doty P. Formylmethionine codon AUG as an initiator of polypeptide synthesis. Science. 1966 Jul 22;153(3734):416–418. doi: 10.1126/science.153.3734.416. [DOI] [PubMed] [Google Scholar]
  17. Zamir A., Leder P., Elson D. A ribosome-catalyzed reaction between N-formylmethionyl-trna and puromycin. Proc Natl Acad Sci U S A. 1966 Dec;56(6):1794–1801. doi: 10.1073/pnas.56.6.1794. [DOI] [PMC free article] [PubMed] [Google Scholar]

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