Erratum

Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E Bianchi, Yousef Al-Abed, Ulf Andersson, Kevin J Tracey, and Daniel J Antoine. (2012) Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1). Mol. Med. 18(2):250–259.

In Table 2 of this paper, the second through fifth lines of the “Histological findings” entry was presented incorrectly and should have been shifted one column to the right; below is what was published:

Histological findings

No abnormalities detected necrosis with mild inflammatory cell infiltration

Centrilobular hepatocyte necrosis with moderate inflammatory cell infiltration (including neutrophil rolling)

Centrilobular hepatocyte detected

No abnormalities

Below is corrected Table 2.

Table 2.

Overview of hepatic histological changes (extent of hepatic damage determined by serum ALT activity) induced by acetaminophen over time in mice and corresponding serum HMGB1 redox status.

Time post-APAP treatmenta	0 h	5 h	15 h	24 h
Histological findings	No abnormalities detected	Centrilobular hepatocyte necrosis with mild inflammatory cell infiltration	Centrilobular hepatocyte necrosis with moderate inflammatory cell infiltration (including neutrophil rolling)	No abnormalities detected
Serum ALT (U/L)b	31 ± 10	2641 ± 1,024c	3,015 ± 801c	3,811 ± 1,514c
Serum HMGB1 cysteine redox status identified	Molecule A	Molecule A + D	Molecule A + D	Molecule D

^aThe corresponding LC-MS/MS characterized redox status of each cysteine within circulating HMGB1 also is given for each time point.

^bData are presented as mean ± SEM with six animals per group.

^cP < 0.01 versus 0 h.