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. Author manuscript; available in PMC: 2013 Jun 1.

Published in final edited form as: Peptides. 2012 Mar 30;35(2):202–211. doi: 10.1016/j.peptides.2012.03.020

(A, B) CLR and CGRP were simultaneously localized in stomach, ileum and colon tissue sections. CGRP-IR was detected in close proximity to CLR-positive neurons. CGRP- and CLR-positive nerve fibers intertwined, and in a few locations, colocalization seemed apparent in the stomach, ileum (arrows) (A), and colon (B). Thus, CGRP is localized nearby CLR, suggesting it could function as a ligand for CLR•RAMP1. Single optical sections are shown, except where noted. Myn, myenteric neurons, cm, circular muscle, nf, nerve fiber. Scale bar = 33 μm.

(A, B) CLR and CGRP were simultaneously localized in stomach, ileum and colon tissue sections. CGRP-IR was detected in close proximity to CLR-positive neurons. CGRP- and CLR-positive nerve fibers intertwined, and in a few locations, colocalization seemed apparent in the stomach, ileum (arrows) (A), and colon (B). Thus, CGRP is localized nearby CLR, suggesting it could function as a ligand for CLR•RAMP1. Single optical sections are shown, except where noted. Myn, myenteric neurons, cm, circular muscle, nf, nerve fiber. Scale bar = 33 μm.