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. Author manuscript; available in PMC: 2013 Feb 2.
Published in final edited form as: Oncogene. 2011 Jul 4;31(5):537–551. doi: 10.1038/onc.2011.267

Figure 2. Epigenetic, non-epigenetic or indirect epigenetic effects of HDACis.

Figure 2

HDACis, such as vorinostat, prevent histone deacetylations leading to transcription activation or repression. HDACis also can affect the acetylation status of transcription factors (E2F, NF-κB, Stats) and other proteins with important biological functions (α-tubulin, Ku70, Hsp90). See text for more detailed information.