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. 2012 May 12;61(6):1533–1542. doi: 10.2337/db11-1528

FIG. 6.

FIG. 6.

Effect of diabetes on basal expression and phosphorylation status of angiogenesis mediators. A: Native and phosphorylated VEGF-R2 levels were determined by immunoblotting. Phospho-VEGF was increased in diabetic BMECs. Data are means ± SEM, n = 3. B: In parallel with increased VEGF-R2 activation, c-src phosphorylation also was increased in diabetes. Data are means ± SEM, n = 4. C: Diabetic endothelial cells have elevated protein tyrosine nitration compared with controls. Data are means ± SEM, n = 6–11. D and E: MMP-2 activity was assessed by gelatin zymography. Although there was no difference in secreted latent and active MMP-2, cell-associated MMP-2 was significantly increased. F: MT1-MMP levels determined by immunoblotting were greater in diabetes. Data are means ± SEM, n = 3–4. *P = 0.0079 diabetes vs. control; #P = 0.029 diabetes vs. control; ψP = 0.015 diabetes vs. control; **P = 0.057 diabetes vs. control (exact Wilcoxon test).