Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1970 Aug;66(4):1052–1058. doi: 10.1073/pnas.66.4.1052

INTERFERON AND CELL DIVISION, I. INHIBITION OF THE MULTIPLICATION OF MOUSE LEUKEMIA L 1210 CELLS In Vitro BY INTERFERON PREPARATIONS

Ion Gresser 1,2,*, Danièle Brouty-Boyé 1,2, Marie-Thérèse Thomas 1,2, Alvaro Macieira-Coelho 1,2
PMCID: PMC335785  PMID: 4319881

Abstract

Mouse interferon preparations inhibited the multiplication of mouse leukemia L 1210 cells in stationary suspension cultures. The degree of inhibition was found to correlate with the antiviral titer of the interferon preparations. The factor(s) responsible for inhibition of L 1210 cell multiplication could not be dissociated from interferon by standard physicochemical means.

Full text

PDF
1052

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baron S., Merigan T. C., McKerlie M. L. Effect of crude and purified interferons on the gowth of uninfected cells in culture. Proc Soc Exp Biol Med. 1966 Jan;121(1):50–52. doi: 10.3181/00379727-121-30694. [DOI] [PubMed] [Google Scholar]
  2. Chany C., Vignal M. Etude du mécanisme de l'étst réfractaiere des cellules à l1 production d'interféron, près inductions répétées. C R Acad Sci Hebd Seances Acad Sci D. 1968 Nov 18;267(21):1798–1800. [PubMed] [Google Scholar]
  3. FINTER N. B. A RICH SOURCE OF MOUSE INTERFERON. Nature. 1964 Dec 12;204:1114–1115. doi: 10.1038/2041114b0. [DOI] [PubMed] [Google Scholar]
  4. Falcoff E., Fournier F., Chany C. Etude comparative des poids moléculaires de deux interférons humains produits in vitro. Ann Inst Pasteur (Paris) 1966 Sep;111(3):241–248. [PubMed] [Google Scholar]
  5. Falcoff R., Falcoff E., Dubouche P., Chany C. Activité biologique des interférons humains sur l'espèce simienne in vitro et in vivo. C R Acad Sci Hebd Seances Acad Sci D. 1968 Jan 15;266(3):297–300. [PubMed] [Google Scholar]
  6. Falcoff R., Fontaine-Brouty D., Falcoff E. Purification partielle et caractérisation de l'interféron provenant de cerveau de souris. Ann Inst Pasteur (Paris) 1968 Aug;115(2):279–287. [PubMed] [Google Scholar]
  7. Fantes K. H., Furminger I. G. Polyacrylamide gel electrophoresis of highly purified chick interferon. Nature. 1967 Oct 7;216(5110):71–72. doi: 10.1038/216071a0. [DOI] [PubMed] [Google Scholar]
  8. Fauconnier B. Antigenic identity of interferons induced by different viruses in the same cell system. Nature. 1967 May 6;214(5088):591–592. doi: 10.1038/214591a0. [DOI] [PubMed] [Google Scholar]
  9. Field A. K., Tytell A. A., Lampson G. P., Hilleman M. R. Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes. Proc Natl Acad Sci U S A. 1967 Sep;58(3):1004–1010. doi: 10.1073/pnas.58.3.1004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. GRESSER I. Production of interferon by suspensions of human leucocytes. Proc Soc Exp Biol Med. 1961 Dec;108:799–803. doi: 10.3181/00379727-108-27072. [DOI] [PubMed] [Google Scholar]
  11. Gresser I., Bourali C. Exogenous interferon and inducers of interferon in the treatment Balb-c mice inoculated with RC19 tumour cells. Nature. 1969 Aug 23;223(5208):844–845. doi: 10.1038/223844a0. [DOI] [PubMed] [Google Scholar]
  12. Gresser I., Bourali C., Lévy J. P., Fontaine-Brouty-Boy0e, Thomas M. T. Prolongation de la survie des souris inoculées avec des cellules tumorales et traitées avec des préparations d'interférons. C R Acad Sci Hebd Seances Acad Sci D. 1969 Feb 10;268(6):994–997. [PubMed] [Google Scholar]
  13. Gresser I., Fontaine-Brouty-Boyé D., Bourali C., Thomas M. T. A comparison of the efficacy of endogenous, exogenous, and combined endogenous-exogenous interferon in the treatment of mice infected with encephalomyocarditis virus. Proc Soc Exp Biol Med. 1969 Jan;130(1):236–242. doi: 10.3181/00379727-130-33529. [DOI] [PubMed] [Google Scholar]
  14. Hanna L., Merigan T. C., Jawetz E. Inhibition of TRIC agents by virus-induced interferon. Proc Soc Exp Biol Med. 1966 Jun;122(2):417–421. doi: 10.3181/00379727-122-31150. [DOI] [PubMed] [Google Scholar]
  15. PAUCKER K., CANTELL K., HENLE W. Quantitative studies on viral interference in suspended L cells. III. Effect of interfering viruses and interferon on the growth rate of cells. Virology. 1962 Jun;17:324–334. doi: 10.1016/0042-6822(62)90123-x. [DOI] [PubMed] [Google Scholar]
  16. Remington J. S., Merigan T. C. Interferon: protection of cells infected with an intracellular protozoan (Toxoplasma gondii). Science. 1968 Aug 23;161(3843):804–806. doi: 10.1126/science.161.3843.804. [DOI] [PubMed] [Google Scholar]
  17. Sueltenfuss E. A., Pollard M. Cytochemical Assay of Interferon Produced by Duck Hepatitis Virus. Science. 1963 Feb 15;139(3555):595–596. doi: 10.1126/science.139.3555.595. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES