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. 2012 Jun 15;139(12):2150–2155. doi: 10.1242/dev.077065

Fig. 2.

Fig. 2.

crabp2a is RA inducible and required for signal robustness. (A-F) Whole-mount ISH for crabp2a/b expression at 15 hpf; dorsal views, anterior left. crabp2a (A-C) is expressed posterior to the R5/6 boundary, whereas crabp2b (D-F) expression is restricted to somites. Treatment with 10 nM RA expands crabp2a expression anteriorly throughout the CNS (B) but has no effect on crabp2b (E). Treatment with 5 μM DEAB eliminates crabp2a expression (C) but does not disrupt crabp2b (F). (G-R) pax2a, krox20 and hoxb4 expression at 18 hpf in uninjected controls (G-I), Crabp2a-MO-injected (J-L) and crabp2a mRNA-injected embryos (M-R) treated with 1 nM RA (H,K), 10 nM RA (I,L,N,Q) or 10 μM DEAB (O,R). so, somites.