Abstract
In this paper a physical model of the neural membrane that I developed is tested for its ability to account for the details of the action potential spikes observed in squid giant axons, when perfused with sodium- and potassium-free fluids and surrounded by a calcium chloride solution. The near-zero resting potential of these perfused axons is accounted for by the model. The sizes, shapes, and conductances of the spikes observed with a number of different perfusates are also accounted for, when suitable values are assigned to the so-far unmeasured membrane constants that control the model properties. The three papers comprising the series are summarized at the end of this paper.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Tasaki I., Lerman L., Watanabe A. Analysis of excitation process in squid giant axons under bi-ionic conditions. Am J Physiol. 1969 Jan;216(1):130–138. doi: 10.1152/ajplegacy.1969.216.1.130. [DOI] [PubMed] [Google Scholar]
- Wooldridge D. E. A spike-forming model of the neural membrane. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3468–3471. doi: 10.1073/pnas.72.9.3468. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wooldridge D. E. Spike-forming model of the neural membrane: computer simulation of some perfused axon experiments. Proc Natl Acad Sci U S A. 1975 Dec;72(12):4859–4862. doi: 10.1073/pnas.72.12.4859. [DOI] [PMC free article] [PubMed] [Google Scholar]