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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Pain. 2012 Apr 13;153(6):1232–1243. doi: 10.1016/j.pain.2012.02.035

Figure 8. Real-time VAS ratings to short-duration stimuli: Hyperalgesia and increased VAS fall slopes.

Figure 8

Maximum ratings to short-duration (4–6 s) stimuli, S.PeakVAS, were increased over time after both naloxone and remifentanil administrations (A, N=19) and under conditions of naloxone, remifentanil and control (B, N=8). VAS fall slopes also became steeper over time under all conditions for both slow stimulus fall rates of 0.5°C/s (C, N=19)(D, N=8) and fast stimulus fall rates of 5.0°C/s (E, N=19)(F, N=8) indicating that temporal sharpening mechanisms were conserved under conditions inducing thermal hyperalgesia.