Skip to main content
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1976 Feb;73(2):585–590. doi: 10.1073/pnas.73.2.585

New gene locus modifying susceptibility to certain B-tropic murine leukemia viruses.

A Declève, O Niwa, J Kojola, H S Kaplan
PMCID: PMC335955  PMID: 174115

Abstract

A new gene, SRV, the dominant allele of which occurs in mice of strain C57BL, independently modifies the slope ("hitness") and level of sensitivity of the titration curves obtained when one subclass of B-tropic murine leukemia viruses is propagated on mouse embryo cells of nonpermissive Fv-1 genotypes. Replication of another subclass of B-tropic viruses is not modified with respect to hitness, and that of N-tropic viruses is not affected.

Full text

PDF
585

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Decleve A., Lieberman M., Niwa O., Kaplan H. S. Rapid in vivo assay for murine lymphatic leukaemia viruses. Nature. 1974 Nov 1;252(5478):79–81. doi: 10.1038/252079a0. [DOI] [PubMed] [Google Scholar]
  2. Declève A., Lieberman M., Hahn G. M., Kaplan H. S. Focus formation by a murine sarcoma leukemia virus complex. II. Quantitative aspects of the interaction between radiation leukemia virus and its murine sarcoma virus pseudotype in strain C57BL mouse embryo cells. J Virol. 1970 Apr;5(4):437–445. doi: 10.1128/jvi.5.4.437-445.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Declève A., Niwa O., Gelmann E., Kaplan H. S. Kinetics of propagation of B-tropic murine leukemia virus on Fv-1b cell lines: requirement for multiple cycles of cell replication for transformation and viral antigen expression by RadLV. Virology. 1975 Feb;63(2):367–383. doi: 10.1016/0042-6822(75)90310-4. [DOI] [PubMed] [Google Scholar]
  4. Declève A., Niwa O., Gelmann E., Kaplan H. S. Replication kinetics of N- and B-tropic murine leukemia viruses on permissive and nonpermissive cells in vitro. Virology. 1975 Jun;65(2):320–332. doi: 10.1016/0042-6822(75)90038-0. [DOI] [PubMed] [Google Scholar]
  5. Declève A., Niwa O., Hilgers J., Kaplan H. S. An improved murine leukemia virus immunofluorescence assay. Virology. 1974 Feb;57(2):491–502. doi: 10.1016/0042-6822(74)90188-3. [DOI] [PubMed] [Google Scholar]
  6. Hartley J. W., Rowe W. P., Huebner R. J. Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures. J Virol. 1970 Feb;5(2):221–225. doi: 10.1128/jvi.5.2.221-225.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Huang A. S., Besmer P., Chu L., Baltimore D. Growth of pseudotypes of vesicular stomatitis virus with N-tropic murine leukemia virus coats in cells resistant to N-tropic viruses. J Virol. 1973 Sep;12(3):659–662. doi: 10.1128/jvi.12.3.659-662.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kaplan H. S. On the natural history of the murine leukemias: presidential address. Cancer Res. 1967 Aug;27(8):1325–1340. [PubMed] [Google Scholar]
  9. Krontiris T. G., Soeiro R., Fields B. N. Host restriction of Friend leukemia virus. Role of the viral outer coat. Proc Natl Acad Sci U S A. 1973 Sep;70(9):2549–2553. doi: 10.1073/pnas.70.9.2549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LIEBERMAN M., KAPLAN H. S. Leukemogenic activity of filtrates from radiation-induced lymphoid tumors of mice. Science. 1959 Aug 14;130(3372):387–388. doi: 10.1126/science.130.3372.387. [DOI] [PubMed] [Google Scholar]
  11. Lieberman M., Niwa O., Declève A., Kaplan H. S. Continuous propagation of radiation leukemia virus on a C57BL mouse-embryo fibroblast line, with attenuation of leukemogenic activity. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1250–1253. doi: 10.1073/pnas.70.4.1250. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lilly F. Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice. J Natl Cancer Inst. 1970 Jul;45(1):163–169. [PubMed] [Google Scholar]
  13. Niwa O., Decléve A., Liberman M., Kaplan H. S. Adaptation of plaque assay methods to the in vitro quantitation of the radiation leukemia virus. J Virol. 1973 Jul;12(1):68–73. doi: 10.1128/jvi.12.1.68-73.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Odaka T. Inheritance of susceptibility to Friend mouse leukemia virus. V. Introduction of a gene responsible for susceptibility in the genetic complement of resistant mice. J Virol. 1969 Jun;3(6):543–548. doi: 10.1128/jvi.3.6.543-548.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Pincus T., Hartley J. W., Rowe W. P. A major genetic locus affecting resistance to infection with murine leukemia viruses. I. Tissue culture studies of naturally occurring viruses. J Exp Med. 1971 Jun 1;133(6):1219–1233. doi: 10.1084/jem.133.6.1219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Pincus T., Hartley J. W., Rowe W. P. A major genetic locus affecting resistance to infection with murine leukemia viruses. IV. Dose-response relationships in Fv-1-sensitive and resistant cell cultures. Virology. 1975 Jun;65(2):333–342. doi: 10.1016/0042-6822(75)90039-2. [DOI] [PubMed] [Google Scholar]
  17. Pincus T., Rowe W. P., Lilly F. A major genetic locus affecting resistance to infection with murine leukemia viruses. II. Apparent identity to a major locus described for resistance to friend murine leukemia virus. J Exp Med. 1971 Jun 1;133(6):1234–1241. doi: 10.1084/jem.133.6.1234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Steck F. T., Rubin H. The mechanism of interference between an avian leukosis virus and Rous sarcoma virus. I. Establishment of interference. Virology. 1966 Aug;29(4):628–641. doi: 10.1016/0042-6822(66)90287-x. [DOI] [PubMed] [Google Scholar]
  19. Sveda M. M., Fields B. N., Soeiro R. Host restriction of friend leukemia virus; fate of input virion RNA. Cell. 1974 Aug;2(4):271–277. doi: 10.1016/0092-8674(74)90021-x. [DOI] [PubMed] [Google Scholar]
  20. TENNANT J. R. Derivation of a murine lymphoid leukemia virus. J Natl Cancer Inst. 1962 Jun;28:1291–1303. [PubMed] [Google Scholar]
  21. Vogt P. K., Ishizaki R. Reciprocal patterns of genetic resistance to avian tumor viruses in two lines of chickens. Virology. 1965 Aug;26(4):664–672. doi: 10.1016/0042-6822(65)90329-6. [DOI] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES