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. 1976 Feb;73(2):646–650. doi: 10.1073/pnas.73.2.646

Activation of an endogenous mouse type C virus by ultraviolet-irradiated herpes simplex virus types 1 and 2.

B Hampar, S A Aaronson, J G Derge, M Chakrabarty, S D Showalter, C Y Dunn
PMCID: PMC335968  PMID: 174117

Abstract

Infection of BALB/c mouse cells with UV-irradiated herpes simplex virus (HSV) types 1 and 2 resulted in activation of a xenotropic type C virus detected by infectious center formation in permissive rat cells. The levels of type C virus activated by HSV were related to the UV dose and the multiplicity of infection used. The ability of HSV to activate type C virus was eliminated by heat-inactivation and by neutralization with specific antiserum against HSV, but was not affected by purification or treatment with DNase and RNase. Maximum levels of type C virus in the cells and medium were observed within 1 day after HSV infection, and the levels returned to control cell values within 3-4 days. The possible significance of these findings with respect to the putative oncogenic potential of HSV is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aaronson S. A., Anderson G. R., Dunn C. Y., Robbins K. C. Induction of type-C RNA virus by cycloheximide: increased expression of virus-specific RNA. Proc Natl Acad Sci U S A. 1974 Oct;71(10):3941–3945. doi: 10.1073/pnas.71.10.3941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aaronson S. A. Chemical induction of focus-forming virus from nonproducer cells transformed by murine sarcoma virus. Proc Natl Acad Sci U S A. 1971 Dec;68(12):3069–3072. doi: 10.1073/pnas.68.12.3069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Aaronson S. A., Dunn C. Y. Endogenous C-type viruses of BALB-c cells: frequencies of spontaneous and chemical induction. J Virol. 1974 Jan;13(1):181–185. doi: 10.1128/jvi.13.1.181-185.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Aaronson S. A., Dunn C. Y. High-frequency C-type virus induction by inhibitors of protein synthesis. Science. 1974 Feb 1;183(4123):422–424. doi: 10.1126/science.183.4123.422. [DOI] [PubMed] [Google Scholar]
  5. Aaronson S. A., Hartley J. W., Todaro G. J. Mouse leukemia virus: "spontaneous" release by mouse embryo cells after long-term in vitro cultivation. Proc Natl Acad Sci U S A. 1969 Sep;64(1):87–94. doi: 10.1073/pnas.64.1.87. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Aaronson S. A., Stephenson J. R. Independent segregation of loci for activation of biologically distinguishable RNA C-type viruses in mouse cells. Proc Natl Acad Sci U S A. 1973 Jul;70(7):2055–2058. doi: 10.1073/pnas.70.7.2055. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Aaronson S. A., Todaro G. J., Scolnick E. M. Induction of murine C-type viruses from clonal lines of virus-free BALB-3T3 cells. Science. 1971 Oct 8;174(4005):157–159. doi: 10.1126/science.174.4005.157. [DOI] [PubMed] [Google Scholar]
  8. Aaronson S. A., Weaver C. A. Characterization of murine sarcoma virus (Kirsten) transformation of mouse and human cells. J Gen Virol. 1971 Nov;13(2):245–252. doi: 10.1099/0022-1317-13-2-245. [DOI] [PubMed] [Google Scholar]
  9. Benveniste R. E., Todaro G. J., Scolnick E. M., Parks W. P. Partial transcription of murine type C viral genomes in BALB c cell lines. J Virol. 1973 Oct;12(4):711–720. doi: 10.1128/jvi.12.4.711-720.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Bronson D. L., Dreesman G. R., Biswal N., Benyesh-Melnick M. Defective virions of herpes simplex viruses. Intervirology. 1973;1(3):141–153. doi: 10.1159/000148841. [DOI] [PubMed] [Google Scholar]
  11. Dougherty R. M., Di Stefano H. S. Lack of relationship between infection with avian leukosis virus and the presence of COFAL antigen in chick embryos. Virology. 1966 Aug;29(4):586–595. doi: 10.1016/0042-6822(66)90282-0. [DOI] [PubMed] [Google Scholar]
  12. Duff R., Rapp F. Oncogenic transformation of hamster cells after exposure to herpes simplex virus type 2. Nat New Biol. 1971 Sep 8;233(36):48–50. doi: 10.1038/newbio233048a0. [DOI] [PubMed] [Google Scholar]
  13. Duff R., Rapp F. Quantitative assay for transformation of 3T3 cells by herpes simplex virus type 2. J Virol. 1975 Mar;15(3):490–496. doi: 10.1128/jvi.15.3.490-496.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Dunn C. Y., Aaronson S. A., Stephenson J. R. Interactions of chemical inducers and steroid enhancers of endogenous mouse type-C RNA viruses. Virology. 1975 Aug;66(2):579–588. doi: 10.1016/0042-6822(75)90230-5. [DOI] [PubMed] [Google Scholar]
  15. Fan H., Baltimore D. RNA metabolism of murine leukemia virus: detection of virus-specific RNA sequences in infected and uninfected cells and identification of virus-specific messenger RNA. J Mol Biol. 1973 Oct 15;80(1):93–117. doi: 10.1016/0022-2836(73)90235-0. [DOI] [PubMed] [Google Scholar]
  16. Freeman A. E., Gilden R. V., Vernon M. L., Wolford R. G., Hugunin P. E., Huebner R. J. 5-Bromo-2'-deoxyuridine potentiation of transformation of rat-embryo cells induced in vitro by 3-methylcholanthrene: induction of rat leukemia virus gs antigen in transformed cells. Proc Natl Acad Sci U S A. 1973 Aug;70(8):2415–2419. doi: 10.1073/pnas.70.8.2415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Hampar B., Stevens D. A., Martos L. M., Ablashi D. V., Burroughs M. A., Wells G. A. Correlation between the neutralizing activity of human serum against Herpes simplex virus and a simian herpesvirus (SA8). J Immunol. 1969 Feb;102(2):397–403. [PubMed] [Google Scholar]
  18. Hartley J. W., Rowe W. P., Huebner R. J. Host-range restrictions of murine leukemia viruses in mouse embryo cell cultures. J Virol. 1970 Feb;5(2):221–225. doi: 10.1128/jvi.5.2.221-225.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Hatanaka M., Klein R., Toni R., Walker J., Gilden R. Mutants of nonproducer cell lines transformed by murine sarcoma viruses. I. Induction, isolation, particle production, and tumorigenicity. J Exp Med. 1973 Aug 1;138(2):356–363. doi: 10.1084/jem.138.2.356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Hayward W. S., Hanafusa H. Detection of avian tumor virus RNA in uninfected chicken embryo cells. J Virol. 1973 Feb;11(2):157–167. doi: 10.1128/jvi.11.2.157-167.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Hirsch M. S., Phillips S. M., Solnik C., Black P. H., Schwartz R. S., Carpenter C. B. Activation of leukemia viruses by graft-versus-host and mixed lymphocyte reactions in vitro. Proc Natl Acad Sci U S A. 1972 May;69(5):1069–1072. doi: 10.1073/pnas.69.5.1069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Huu Duc-Nguyen, Rosenblum E. N., Zeigel R. F. Persistent infection of a rat kidney cell line with Rauscher murine leukemia virus. J Bacteriol. 1966 Oct;92(4):1133–1140. doi: 10.1128/jb.92.4.1133-1140.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Klement V., Nicolson M. O., Huebner R. J. Rescue of the genome of focus forming virus from rat non-productive lines by 5'-bromodeoxyruidine. Nat New Biol. 1971 Nov 3;234(44):12–14. doi: 10.1038/newbio234012a0. [DOI] [PubMed] [Google Scholar]
  24. LIEBERMAN M., KAPLAN H. S. Leukemogenic activity of filtrates from radiation-induced lymphoid tumors of mice. Science. 1959 Aug 14;130(3372):387–388. doi: 10.1126/science.130.3372.387. [DOI] [PubMed] [Google Scholar]
  25. Levy J. A. Xenotropic viruses: murine leukemia viruses associated with NIH Swiss, NZB, and other mouse strains. Science. 1973 Dec 14;182(4117):1151–1153. doi: 10.1126/science.182.4117.1151. [DOI] [PubMed] [Google Scholar]
  26. Lowy D. R., Rowe W. P., Teich N., Hartley J. W. Murine leukemia virus: high-frequency activation in vitro by 5-iododeoxyuridine and 5-bromodeoxyuridine. Science. 1971 Oct 8;174(4005):155–156. doi: 10.1126/science.174.4005.155. [DOI] [PubMed] [Google Scholar]
  27. Meléndez L. V., Hunt R. D., Daniel M. D., García F. G., Fraser C. E. Herpesvirus saimiri. II. Experimentally induced malignant lymphoma in primates. Lab Anim Care. 1969 Jun;19(3):378–386. [PubMed] [Google Scholar]
  28. Okabe H., Gilden R. V., Hatanaka M. RD 114 virus-specific sequences in feline cellular RNA: detection and characterization. J Virol. 1973 Nov;12(5):984–994. doi: 10.1128/jvi.12.5.984-994.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Oroszlan S., Foreman C., Kelloff G., Gilden R. V. The group-specific antigen and other structural proteins of hamster and mouse C-type viruses. Virology. 1971 Mar;43(3):665–674. doi: 10.1016/0042-6822(71)90290-x. [DOI] [PubMed] [Google Scholar]
  30. Temin H. M. Mechanism of cell transformation by RNA tumor viruses. Annu Rev Microbiol. 1971;25:609–648. doi: 10.1146/annurev.mi.25.100171.003141. [DOI] [PubMed] [Google Scholar]
  31. Toyoshima K., Vogt P. K. Enhancement and inhibition of avian sarcoma viruses by polycations and polyanions. Virology. 1969 Jul;38(3):414–426. doi: 10.1016/0042-6822(69)90154-8. [DOI] [PubMed] [Google Scholar]

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