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Upper panel, P. aeruginosa infection increases the size and aggressiveness of cholesteatomas. The Otopathogenic strain (OPPA8) causes the most growth. PA14 and OPPA8-NP cause modest growth compared to controls but significantly less than OPPA8. DH5α (E. coli) causes no more enlargement than the control (vehicle only). Lower panel, Significant bone erosion was seen with infection with OPPA8 and PA14 but not with OPPA8-NP or DH5α.
