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. 1978 Sep;75(9):4234–4237. doi: 10.1073/pnas.75.9.4234

Ca2+-related regulatory function of fibrinogen.

R B Credo, C G Curtis, L Lorand
PMCID: PMC336086  PMID: 279911

Abstract

Fibrinogen displays a regulation of considerable physiological significance by lowering the Ca2+ requirement for the conversion of the fibrin-stabilizing factor (Factor XIII) zymogen to the range of concentrations of this ion found in plasma. Fibrinogen modulates both Ca2+-dependent steps in the complex process of zymogen activation, involving the heterologous dissociation of subunits of the thrombin-modified zymogen (Factor XIII') species : formula: (see text) and the unmasking of iodoacetamide titratable sites during generation of transamidating activity : formula: (see text). It is interesting that a thrombin-independent pathway of zymogen activation : formula: (see text), which we found to operate at Ca2+ concentrations above 50 mM, is not affected by the presence of fibrinogen. Regulation by fibrinogen thus appears to be specific for controlling only the physiological pathway of zymogen conversion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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