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. 1978 Sep;75(9):4460–4464. doi: 10.1073/pnas.75.9.4460

Another chromosomal assignment for a simian virus 40 integration site in human cells.

R Kucherlapati, S P Hwang, N Shimizu, J K McDougall, M R Botchan
PMCID: PMC336135  PMID: 212753

Abstract

Somatic cell hybrids derived from fusion of GM637, a human cell line transformed by simian virus 40, and mouse B82 cells were examined for simian virus 40 T antigen, V antigen, and viral DNA. All hybrid cell lines that contained viral DNA were T-antigen positive. Cells that did not have viral DNA were T-antigen negative. We determined that there is a single viral insertion in these hybrid cells. Correlation of T-antigen expression and viral DNA with the partial complements of the human genome retained in the hybrids shwed that the inserted viral genome is in human chromosome 8. The integrated viral DNA is stable; free viral DNA found in GM637 does not insert at other potential sites in the human genome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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