Abstract
Somatostatin in concentrations of 10(-6) to 10(-8) M inhibited basal release of thyrotropin releasing factor in organ culture of rat hypothalamus. Norepinephrine in doses of 10(-4)--10(-6) M induced release of thyrotropin releasing factor which increased progressively with time and was temperature and dose dependent. This enhanced thyrotropin-releasing-factor release was inhibited by somatostatin at 10(-6)--10(-8) M.
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Selected References
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- Arimura A., Schally A. V. Increase in basal and thyrotropin-releasing hormone (TRH)-stimulated secretion of thyrotropin (TSH) by passive immunization with antiserum to somatostatin in rats. Endocrinology. 1976 Apr;98(4):1069–1072. doi: 10.1210/endo-98-4-1069. [DOI] [PubMed] [Google Scholar]
- Bassiri R. M., Utiger R. D. Thyrotropin-releasing hormone in the hypothalamus of the rat. Endocrinology. 1974 Jan;94(1):188–197. doi: 10.1210/endo-94-1-188. [DOI] [PubMed] [Google Scholar]
- Bassiri R., Utiger R. D. Serum inactivation of the immunological and biological activity of thyrotropin releasing hormone (TRH). Endocrinology. 1972 Sep;91(3):657–664. doi: 10.1210/endo-91-3-657. [DOI] [PubMed] [Google Scholar]
- Brownstein M., Arimura A., Sato H., Schally A. V., Kizer J. S. The regional distribution of somatostatin in the rat brain. Endocrinology. 1975 Jun;96(6):1456–1461. doi: 10.1210/endo-96-6-1456. [DOI] [PubMed] [Google Scholar]
- Dubois M. P. Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas. Proc Natl Acad Sci U S A. 1975 Apr;72(4):1340–1343. doi: 10.1073/pnas.72.4.1340. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Eskay R. L., Mical R. S., Porter J. C. Relationship between luteinizing hormone releasing hormone concentration in hypophysial portal blood and luteinizing hormone release in intact, castrated, and electrochemically-stimulated rats. Endocrinology. 1977 Feb;100(2):263–270. doi: 10.1210/endo-100-2-263. [DOI] [PubMed] [Google Scholar]
- Griffiths E. C., Jeffcoate S. L., Holland D. T. Inactivation of somatostatin by peptidases in different areas of the rat brain. Acta Endocrinol (Copenh) 1977 May;85(1):1–10. doi: 10.1530/acta.0.0850001. [DOI] [PubMed] [Google Scholar]
- Grimm Y., Reichlin S. Thyrotropin releasing hormone (TRH): neurotransmitter regulation of secretion by mouse hypothalamic tissue in vitro. Endocrinology. 1973 Sep;93(3):626–631. doi: 10.1210/endo-93-3-626. [DOI] [PubMed] [Google Scholar]
- Hökfelt T., Fuxe K., Johansson O., Jeffcoate S., White N. Distribution of thyrotropin-releasing hormone (TRH) in the central nervous system as revealed with immunohistochemistry. Eur J Pharmacol. 1975 Dec;34(2):389–392. doi: 10.1016/0014-2999(75)90269-1. [DOI] [PubMed] [Google Scholar]
- Jackson I. M., Reichlin S. Brain thyrotrophin-releasing hormone is independent of the hypothalamus. Nature. 1977 Jun 30;267(5614):853–854. doi: 10.1038/267853a0. [DOI] [PubMed] [Google Scholar]
- Jackson I. M., Reichlin S. Thyrotropin-releasing hormone (TRH): distribution in hypothalamic and extrahypothalamic brain tissues of mammalian and submammalian chordates. Endocrinology. 1974 Sep;95(3):854–862. doi: 10.1210/endo-95-3-854. [DOI] [PubMed] [Google Scholar]
- Koerker D. J., Ruch W., Chideckel E., Palmer J., Goodner C. J., Ensinck J., Gale C. C. Somatostatin: hypothalamic inhibitor of the endocrine pancreas. Science. 1974 Apr 26;184(4135):482–484. doi: 10.1126/science.184.4135.482. [DOI] [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Ling N., Burgus R., Rivier J., Vale W., Brazeau P. The use of mass spectrometry in deducing the sequence of somatostatin--a hypothalamic polypeptide that inhibits the secretion of growth hormone. Biochem Biophys Res Commun. 1973 Jan 4;50(1):127–133. doi: 10.1016/0006-291x(73)91073-5. [DOI] [PubMed] [Google Scholar]
- Maruyama T., Ishikawa H. Somatostatin: its inhibiting effect on the release of hormones and IgG, from clonal cells strains its Ca-influx dependence. Biochem Biophys Res Commun. 1977 Feb 7;74(3):1083–1088. doi: 10.1016/0006-291x(77)91629-1. [DOI] [PubMed] [Google Scholar]
- McKelvy J. F. Biochemical neuroendocrinology. I. Biosynthesis of thyrotropin releasing hormone (TRH) by organ cultures of mammalian hypothalamus. Brain Res. 1974 Jan 18;65(3):489–502. doi: 10.1016/0006-8993(74)90237-6. [DOI] [PubMed] [Google Scholar]
- McKelvy J. F., Sheridan M., Joseph S., Phelps C. H., Perrie S. Biosynthesis of thyrotropin-releasing hormone in organ cultures of the guinea pig median eminence. Endocrinology. 1975 Oct;97(4):908–918. doi: 10.1210/endo-97-4-908. [DOI] [PubMed] [Google Scholar]
- Mitsuma T., Hirooka Y., Nihei N. Radioimmunoassay of thyrotrophin releasing hormone in human serum and its clinical application. Acta Endocrinol (Copenh) 1976 Oct;83(2):225–235. doi: 10.1530/acta.0.0830225. [DOI] [PubMed] [Google Scholar]
- Mitsuma T., Hirooka Y., Nihei N. [The effect of various amines on TRH contents in rat brain (author's transl)]. Nihon Naibunpi Gakkai Zasshi. 1976 Aug 20;52(8):806–813. doi: 10.1507/endocrine1927.52.8_806. [DOI] [PubMed] [Google Scholar]
- Pelletier G., Dubé D., Puviani R. Somatostatin: electron microscope immunohistochemical localization in secretory neurons of rat hypothalamus. Science. 1977 Jun 24;196(4297):1469–1470. doi: 10.1126/science.867046. [DOI] [PubMed] [Google Scholar]
- Plotnikoff N. P., Prange A. J., Jr, Breese G. R., Anderson M. S., Wilson I. C. Thyrotropin releasing hormone: enhancement of dopa activity by a hypothalamic hormone. Science. 1972 Oct 27;178(4059):417–418. doi: 10.1126/science.178.4059.417. [DOI] [PubMed] [Google Scholar]
- Porter J. C., Smith K. R. Collection of hypophysial stalk blood in rats. Endocrinology. 1967 Nov;81(5):1182–1185. doi: 10.1210/endo-81-5-1182. [DOI] [PubMed] [Google Scholar]
- Renaud L. P., Martin J. B. Thyrotropin releasing hormone (TRH): depressant action on central neuronal activity. Brain Res. 1975 Mar 14;86(1):150–154. doi: 10.1016/0006-8993(75)90648-4. [DOI] [PubMed] [Google Scholar]
- Rodbard D., Frazier G. R. Statistical analysis of radioligand assay data. Methods Enzymol. 1975;37:3–22. doi: 10.1016/s0076-6879(75)37003-1. [DOI] [PubMed] [Google Scholar]
- Sachs H., Goodman R., Osinchak J., McKelvy J. Supraoptic neurosecretory neurons of the guinea pig in organ culture. Biosynthesis of vasopressin and neurophysin. Proc Natl Acad Sci U S A. 1971 Nov;68(11):2782–2786. doi: 10.1073/pnas.68.11.2782. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Silverman A. J., Knigge K. M., Ribas J. L., Sheridan M. N. Transport capacity of median eminence. 3. Amino acid and thyroxine transport of organ-cultured median eminence. Neuroendocrinology. 1973;11(2):107–118. doi: 10.1159/000122123. [DOI] [PubMed] [Google Scholar]
- Vale W., Brazeau P., Rivier C., Brown M., Boss B., Rivier J., Burgus R., Ling N., Guillemin R. Somatostatin. Recent Prog Horm Res. 1975;31:365–397. doi: 10.1016/b978-0-12-571131-9.50014-1. [DOI] [PubMed] [Google Scholar]
- Vale W., Rivier C., Brazeau P., Guillemin R. Effects of somatostatin on the secretion of thyrotropin and prolactin. Endocrinology. 1974 Oct;95(4):968–977. doi: 10.1210/endo-95-4-968. [DOI] [PubMed] [Google Scholar]
- Weeke J., Hansen A. P., Lundaek K. Inhibition by somatostatin of basal levels of serum thyrotropin (TSH) in normal men. J Clin Endocrinol Metab. 1975 Jul;41(1):168–171. doi: 10.1210/jcem-41-1-168. [DOI] [PubMed] [Google Scholar]
- Winokur A., Utiger R. D. Thyrotropin-releasing hormone: regional distribution in rat brain. Science. 1974 Jul 19;185(4147):265–267. doi: 10.1126/science.185.4147.265. [DOI] [PubMed] [Google Scholar]