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. 1978 Oct;75(10):4940–4943. doi: 10.1073/pnas.75.10.4940

Mechanism of phage Mu-1 integration: nalidixic acid treatment causes clustering of Mu-1-induced mutations near replication origin.

L Paolozzi, R Jucker, E Calef
PMCID: PMC336237  PMID: 283404

Abstract

Frequencies of Mu-1-induced mutants of Escherichia coli have been compared under two different experimental conditions: cells in exponential growth and the same cells treated with nalidixic acid. The average of values obtained from the nalidixic acid-treated culture is 3 times higher than that obtained from the control. Individual ratios of the frequency of mutants in the two cultures yield decreasing values from 6 to 1, starting from the point of origin of DNA replication to the termini of DNA replication. These results are compatible with the idea that Mu-1 integrates at the replication fork.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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