Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1978 Oct;75(10):5090–5093. doi: 10.1073/pnas.75.10.5090

Extent of genetic variation at a highly polymorphic esterase locus in Drosophila pseudoobscura.

J A Coyne, A A Felton, R C Lewontin
PMCID: PMC336269  PMID: 283418

Abstract

The esterase-5 locus of Drosophila pseudoobscura has been screened for variation by using a wide variety of electrophoretic conditions and by testing heat sensitivity. Among 50 isogenic lines from 17 populations, 21 genetic variants were found at the locus, 18 by electrophoresis and 3 by heat denaturation. Including alleles previously known, there are a total of 30 alleles at this locus in natural populations. This represents a doubling of the previous estimates of polymorphism at this locus. The study confirms that, in contrast to monomorphic loci, loci judged polymorphic under one detection procedure show large increases in polymorphism when examined extensively.

Full text

PDF
5090

Images in this article

5092Image
on p.5092
5092Image
on p.5092
5092Image
on p.5092
5092Image
on p.5092

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beckenbach A. T., Prakash S. Examination of Allelic Variation at the Hexokinase Loci of DROSOPHILA PSEUDOOBSCURA and D. PERSIMILIS by Different Methods. Genetics. 1977 Dec;87(4):743–761. doi: 10.1093/genetics/87.4.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cobbs G. Polymorphism for dimerizing ability at the esterase-5 locus in Drosophila pseudoobscura. Genetics. 1976 Jan;82(1):53–62. doi: 10.1093/genetics/82.1.53. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Coyne J. A., Felton A. A. Genic Heterogeneity at Two Alcohol Dehydrogenase Loci in DROSOPHILA PSEUDOOBSCURA and DROSOPHILA PERSIMILIS. Genetics. 1977 Oct;87(2):285–304. doi: 10.1093/genetics/87.2.285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Coyne J. A. Lack of genic similarity between two sibling species of drosophila as revealed by varied techniques. Genetics. 1976 Nov;84(3):593–607. doi: 10.1093/genetics/84.3.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hubby J. L., Lewontin R. C. A molecular approach to the study of genic heterozygosity in natural populations. I. The number of alleles at different loci in Drosophila pseudoobscura. Genetics. 1966 Aug;54(2):577–594. doi: 10.1093/genetics/54.2.577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. King J. L., Ohta T. Polyallelic mutational equilibria. Genetics. 1975 Apr;79(4):681–691. doi: 10.1093/genetics/79.4.681. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lewontin R. C., Ginzburg L. R., Tuljapurkar S. D. Heterosis as an explanation for large amounts of genic polymorphism. Genetics. 1978 Jan;88(1):149–169. doi: 10.1093/genetics/88.1.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McDowell R. E., Prakash S. Allelic heterogeneity within allozymes separated by electrophoresis in Drosophila pseudoobscura. Proc Natl Acad Sci U S A. 1976 Nov;73(11):4150–4153. doi: 10.1073/pnas.73.11.4150. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Prakash S. Genic variation in a natural population of Drosophila persimilis. Proc Natl Acad Sci U S A. 1969 Mar;62(3):778–784. doi: 10.1073/pnas.62.3.778. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Singh R. S., Lewontin R. C., Felton A. A. Genetic heterogeneity within electrophoretic "alleles" of xanthine dehydrogenase in Drosophila pseudoobscura. Genetics. 1976 Nov;84(3):609–629. doi: 10.1093/genetics/84.3.609. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES