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. 1988 Mar 25;16(6):2553–2564. doi: 10.1093/nar/16.6.2553

A putative ancestral actin gene present in a thermophilic eukaryote: novel combination of intron positions.

A G Wildeman 1
PMCID: PMC336389  PMID: 3362675

Abstract

The gene encoding actin in the thermophilic fungus Thermomyces lanuginosus has been isolated and sequenced. It contains five introns, with three being at positions already known to be intron sites in actin genes from other eukaryotes. These three positions have not been found to occur simultaneously in any other organisms to date, suggesting that the actin gene in this fungus may more closely resemble an ancestral form of this highly conserved eukaryotic gene. The 5' flanking region of the gene contains a TATA-like sequence and two CCAAT motifs in positions almost identical to those in the yeast actin gene. Other features of the gene sequence, and possible adaptations to thermophily, are discussed.

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Selected References

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