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. 1988 Apr 11;16(7):2959–2969. doi: 10.1093/nar/16.7.2959

Intergenic exchange maintains identity between two human lambda light chain immunoglobulin gene intron sequences.

J A Udey 1, B B Blomberg 1
PMCID: PMC336444  PMID: 3130611

Abstract

Evidence for gene conversion or unequal double crossover in the human lambda light chain immunoglobulin locus is presented. The high level of J2C2-J3C3 intron cross-hybridization, the identity of the J lambda and J lambda 3 coding and intron sequences, the presence of multiple base differences between the C lambda 2 and C lambda 3 coding regions, and the presence of both the unconverted and converted alleles in the normal gene pool, suggest that a recombinational event has resulted in the conversion of the J lambda 2 coding and intron sequences to those of J lambda 3 and its flanking sequences. Intergenic exchanges, such as the one described here, may provide a mechanism to maintain sequence homogeneity and functionality among the duplicated members of the human lambda gene family.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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