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. 1988 May 11;16(9):4069–4076. doi: 10.1093/nar/16.9.4069

Accuracy of intrachromosomal gene conversion in mouse cells.

J L Stachelek 1, R M Liskay 1
PMCID: PMC336575  PMID: 2836809

Abstract

Results of several recent studies suggest that homologous recombination and related processes in mammalian cells are highly mutagenic. We have examined the products of intrachromosomal gene conversion events that encompassed the last intron of the chicken thymidine kinase gene. Following plasmid rescue and DNA sequencing, we find no mutations associated with twenty conversion events representing 5380 total base pairs of which 2414 base pairs are intron sequence. Based on these studies we conclude that intrachromosomal gene conversion in mouse cells is not a highly mutagenic process but rather it operates with fidelity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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