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. 1988 May 25;16(10):4651–4665. doi: 10.1093/nar/16.10.4651

Interruptions of (CG)n sequences by GG, TG and CA need not prevent B to Z transition in solution.

R K Mishra 1, P K Latha 1, S K Brahmachari 1
PMCID: PMC336655  PMID: 3380692

Abstract

Oligonucleotides containing alternating purines-pyrimidines with AT base pairs have been shown to exist in the Z-form preferably in solid state. We report that oligodeoxyribonucleotides with GG, TG and CA interruptions in their alternating CG sequences can undergo B to Z transition in solution in the absence of any chemical modification or topological constraint. The sequences, d(CGCGCGGCGCGC) and d(CGTGCGCACG) have been synthesised and shown to adopt Z- conformation in presence of millimolar concentrations of Ni2+ under low water activity conditions. Significance of GG, TG and CA interruptions in the B to Z transition is discussed.

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Selected References

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