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Three doses of IVM were evaluated to determine the IVM disposition in both plasma and brain tissue. IVM produced a dose-dependent increase in detectable IVM levels in plasma and brain tissue.
| IVM Dose (mg/kg) | % Reduction of Ethanol Consumption | IVM Plasma AUC0-8 (ng*hr/mL) | IVM Brain AUC (ng*hr/mg) |
|---|---|---|---|
| 0.25 | No Effect | 48.91 | 9.6×10−05 |
| 2.5 | 32 % | 155.56 | 2.8×10−01 |
| 10 | > 50% | 2928.31 | 2.20×1000 |
