Table 4. Group Differences in Connectivity.
| Seed region | Target region | MNI coordinates | Peak Z | Voxels (KE) |
Cannabis correlations: Pearson ‘r' (p-value) |
||||
|---|---|---|---|---|---|---|---|---|---|
| x, y, z | Dosea | Onsetb | Salivac | Urined | Withdrawale | ||||
| Cannabis users>controls | |||||||||
| Anterior cingulate | Right occipitoparietal cortex | 20, −58, 38 | 3.70 | 34 | 0.04 ( 0.85) | −0.11 (0.66) | −0.19 (0.41) | 0.06 (0.82) | 0.10 (0.67) |
| Left occipitoparietal cortex | −24, −62, 26 | 3.62 | 23 | 0.11 (0.66) | 0.30 (0.21) | 0.15 (0.53) | 0.12 (0.67) | −0.25 (0.29) | |
| Left lateral prefrontal | Left occipitoparietal cortex | −26, −62, 26 | 3.54 | 10 | 0.11 (0.65) | 0.51 (0.025) | 0.13 (0.60) | 0.10 (0.70) | −0.30 (0.18) |
| Right lateral prefrontal | Left occipitoparietal cortex | −26, −64, 28 | 2.96 | f | 0.52 (0.024) | 0.68 (0.001) | 0.13 (0.57) | 0.09 (0.75) | −0.34 (0.13) |
| Left insula | Left occipitoparietal cortex | −26, −64, 24 | 3.40 | 6 | 0.02 (0.94) | 0.09 (0.73) | 0.18 (0.44) | −0.15 (0.58) | −0.35 (0.12) |
| Right insula | Left occipitoparietal cortex | −26, −62, 24 | 3.47 | 16 | −0.25 (0.29) | 0.15 (0.53) | 0.24 (0.30) | −0.22 (0.41) | −0.22 (0.33) |
| Controls>cannabis users | |||||||||
| None | |||||||||
a
Total lifetime cannabis use, controlling for onset age and current age.
b
Age of onset of regular cannabis use, controlling for dose and current age.
c
Delta-9 THC concentration by volume in saliva.
d
Carboxy-THC:creatinine ratio in urine.
e
Withdrawal symptoms based on Marijuana Withdrawal Checklist.
f
No voxels were significant at p<0.001 (peak voxel: p=0.002). Bold entries indicate statistically significant correlations.