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. 1988 Mar 11;16(5 Pt A):1729–1738. doi: 10.1093/nar/16.5.1729

Objective comparison of exon and intron sequences by means of 2-dimensional data analysis methods.

L Bougueleret 1, F Tekaia 1, I Sauvaget 1, J M Claverie 1
PMCID: PMC338167  PMID: 3353220

Abstract

Here we advocate the use of 2-dimensional data representation in the context of the informational approach of sequence analysis (Claverie & Bougueleret (1986) Nucleic Acids Research 14, 179-196) by applying these methods to the problem of intron/exon discrimination. Two main findings are reported: i) oligonucleotide patterns complementary to the Ul small nuclear RNA are specifically avoided in exon sequences, ii) vertebrate intron sequences, to the exclusion of other eukaryotic phyla, are characterized by a peculiar distribution of CpG containing patterns.

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Selected References

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