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Immunohistochemistry for p62/SQSTM1 (A and D) and assembled tau (AT100; B and E) showed co-localization in P301S tau transgenic mice (F) but not in wild-type animals (C). Scale bar = 20 µm. (G) Western blot of p62/SQSTM1 levels in the brains of wild-type controls and mice transgenic for human mutant P301S tau that received either no treatment or were given sucrose or trehalose. The amount of p62/SQSTM1 signal is shown normalized with respect to GAPDH. *P < 0.05 and **P < 0.01.
