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. 1988 Aug 11;16(15):7633–7645. doi: 10.1093/nar/16.15.7633

Synthesis of nucleic acid methylphosphonothioates.

H C Roelen 1, E de Vroom 1, G A van der Marel 1, J H van Boom 1
PMCID: PMC338431  PMID: 3412896

Abstract

The reagent obtained in situ by treating methylphosphonothioic dichloride with 1-hydroxy-6-trifluoromethylbenzotriazole could be used for the introduction of methylphosphonothioate linkages. The individual diastereomers of the protected dimer d-Tp(S,Me)A were applied in the synthesis of the chiral pure (R or S) hexamers d-[CpCpTp(S,Me)ApGpG]. The reagent showed also to be very effective for the preparation of the 3',5'-cyclic methylphosphonothioate of uridine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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