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. Author manuscript; available in PMC: 2013 Jan 1.

Published in final edited form as: Laryngoscope. 2011 Nov 22;122(1):174–189. doi: 10.1002/lary.22392

FVB/N mice were fed AR42 for 3 months and blood-brain barrier penetration assays were performed. (A) All mice in this study gained weight and displayed no clinical signs of toxicity. (B) The estimated mean AR42 dose was 34.4 mg/kg/day for this group. (C) AR42 was detected in the brains of all mice analyzed but concentrations were highly variable.

FVB/N mice were fed AR42 for 3 months and blood-brain barrier penetration assays were performed. (A) All mice in this study gained weight and displayed no clinical signs of toxicity. (B) The estimated mean AR42 dose was 34.4 mg/kg/day for this group. (C) AR42 was detected in the brains of all mice analyzed but concentrations were highly variable.