We wish to retract the article titled “TREM-2 Mediated Signaling Induces Antigen Uptake and Retention in Mature Myeloid Dendritic Cells,” by Suresh Radhakrishnan, Laura N. Arneson, Jadee L. Upshaw, Charles L. Howe, Sara J. Felts, Marco Colonna, Paul J. Leibson, Moses Rodriguez, and Larry R. Pease, The Journal of Immunology, 2008, 181: 7863–7872.
In the course of investigating suspicious patterns of experimental results in the laboratory, a systematic and in-depth study of key findings in this article was carried out using blinded protocols. In these repeat studies, no evidence was found to support our original conclusions that B7-DC XAb modulates dendritic cell functions. We do not believe our failure to reproduce our earlier findings is the result of a technical problem. A member of the B7-DC XAb investigative team, Dr. Suresh Radhakrishnan, who was involved in or had access to all the work on this subject, was found in a formal investigation to have engaged in scientific misconduct in unpublished experiments involving the B7-DC XAb reagent. This finding of misconduct and our inability to reproduce key findings using blinded protocols has undermined our confidence in our published reports. We seek, therefore, to retract this body of work.
-
Laura N. Arneson
University of Minnesota Law School
Minneapolis, MN
-
Jadee L. Upshaw
Charles L. Howe
Sara J. Felts
Moses Rodriguez
Larry R. Pease
Mayo Clinic
Rochester, MN
-
Marco Colonna
Washington University
St. Louis, MO