Abstract
Objectives
To compare the bone mineral density (BMD) and its variables in premenopausal and postmenopausal women.
Methods
In this cross sectional study, 62 premenopausal and 62 postmenopausal apparently healthy women were evaluated by a questionnaire. The dietary intake of calcium was evaluated by 24 hours recall method and using table for proximate principle of common Indian food by Indian Council of Medical Research (ICMR). BMD at lumbar spine, femoral neck and Ward’s triangle were measured by dual energy X-ray absorptiometry (DXA). A correlation between BMD and various variables were calculated for each of the two groups.
Results
The mean age of premenopausal and postmenopausal women was 32.46±7.8 and 51.74±7.1 years respectively. The body mass index (BMI), height and weight were comparable in both the groups. The daily intake of calcium was significantly higher in premenopausal women (p<0.01). Approximately, 17% of the postmenopausal women and 9.6% of the premenopausal women were having osteoporosis; 28.56% of the postmenopausal women and 43.54% of the premenopausal women were having osteopenia at the lumbar spine. The BMD at lumber spine was found to be statistically significantly higher in premenopausal women than that in postmenopausal women (p=0.03). BMD at lumbar spine, femoral neck and Ward’s triangle were positively correlated with height, weight, BMI in premenopausal as well in postmenopausal women.
Conclusion
A significant number of women had osteopenia during premenopausal period and osteoporosis in postmenopausal phase. By increasing awareness towards bone health in second and third decade, morbidity of osteoporosis can be reduced.
Key words: osteoporosis, osteopenia, dietary calcium, premenopausal women
Full Text
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References
- 1.Gopalan C, Rama Sastri BV, Balasubramanian SC. Nutritive value of Indian foods. Hyderabad, National Institute of Nutrition, 2004:47–58.
- 2.Gilsanz V., Gibbens D.T., Carlson M., et al. Peak trabecular vertebral density: a comparison of adolescent and adult female. Calcif Tissue Int. 1998;43:260–262. doi: 10.1007/BF02555144. [DOI] [PubMed] [Google Scholar]
- 3.Lane J.M., Nydick M. Osteoporosis: current modes of prevention and treatment. J Am Acad Orthop Surg. 1999;7:19–31. doi: 10.5435/00124635-199901000-00003. [DOI] [PubMed] [Google Scholar]
- 4.Ravn P., Cizza G., Bjarnason N.H., et al. Low body mass index is an important risk factor for low bone mass and increased bone loss in early postmenopausal women. Early Postmenopausal Intervention Cohort (EPIC) study group. J Bone Miner Res. 1999;14:1622–1627. doi: 10.1359/jbmr.1999.14.9.1622. [DOI] [PubMed] [Google Scholar]
- 5.Bjarnason N.H., Christiansen C. The influence of thinness and smoking on bone loss and response to hormone replacement therapy in early postmenopausal women. J Clin Endocrinol Metab. 2000;85:590–596. doi: 10.1210/jc.85.2.590. [DOI] [PubMed] [Google Scholar]
- 6.Eddy D.M., Johnson C.C., Cummings S.R., et al. Osteoporosis: review of the evidence for prevention, diagnosis, and treatment and cost-effectiveness analysis. Osteoporos Int. 1998;8:S3–S6. [PubMed] [Google Scholar]
- 7.Black D.M., Steinbuch M., Palermo L., et al. An assessment tool for predicting fracture risk in postmenopausal women. Osteoporos Int. 2001;12:519–528. doi: 10.1007/s001980170072. [DOI] [PubMed] [Google Scholar]
- 8.Bauer D.C., Browner W.S., Cauley J.A., et al. Factor associated with appendicular bone mass in older women. Ann Intern Med. 1993;118:657–665. doi: 10.7326/0003-4819-118-9-199305010-00001. [DOI] [PubMed] [Google Scholar]
- 9.Reid I.R., Legge M., Stapleton J.P., et al. Regular exercise dissociates fat mass and bone mineral density in premenopausal women. J Clin Endocrinol Metab. 1995;80:1764–1768. doi: 10.1210/jc.80.6.1764. [DOI] [PubMed] [Google Scholar]
- 10.Melton L.J. The prevalence of osteoporosis: gender and racial comparison. Calcif Tissue Int. 2001;69:179–181. doi: 10.1007/s00223-001-1043-9. [DOI] [PubMed] [Google Scholar]
- 11.Uusi-Rasi K., Sievanen H., Vuori I., et al. Association of physical activity and calcium intake with bone mass and size in healthy women at different ages. J Bone Miner Res. 1998;13:133–142. doi: 10.1359/jbmr.1998.13.1.133. [DOI] [PubMed] [Google Scholar]
- 12.Heinonen A., Oja P., Kannus P. Bone mineral density in female athletes representing sports with different loading characteristics of the skeleton. Bone. 1995;17:197–203. doi: 10.1016/8756-3282(95)00151-3. [DOI] [PubMed] [Google Scholar]
- 13.Arya V., Bhambri R., Godbole M.M., et al. Vitamin D status and its relationship with bone mineral density in healthy Asian Indians. Osteoporos Int. 2004;15:56–61. doi: 10.1007/s00198-003-1491-3. [DOI] [PubMed] [Google Scholar]
