Skip to main content
World Journal of Gastroenterology logoLink to World Journal of Gastroenterology
. 2012 Jul 14;18(26):3420–3425. doi: 10.3748/wjg.v18.i26.3420

Safety and effectiveness of propofol sedation during and after outpatient colonoscopy

Akira Horiuchi 1,2,3, Yoshiko Nakayama 1,2,3, Masashi Kajiyama 1,2,3, Naoyuki Kato 1,2,3, Tetsuya Kamijima 1,2,3, Yasuyuki Ichise 1,2,3, Naoki Tanaka 1,2,3
PMCID: PMC3396195  PMID: 22807612

Abstract

AIM: To study the safety and effectiveness of propofol sedation for outpatient colonoscopy.

METHODS: Propofol was given by bolus injection with an age-adjusted standard protocol consisting of 60 mg for patients < 70 years old, 40 mg for patients age 70-89 years, and 20 mg for those ≥ 90 years, and additional injections of 20 mg propofol were given up to a maximum of 200 mg. The principal parameters were the occurrence of adverse events within 24 h after colonoscopy and overall satisfaction for this procedure. Secondary parameters included successful procedure, respiratory depression, and other complications.

RESULTS: Consecutive patients were entered prospectively and all 2101 entered successfully completed outpatient colonoscopy. The mean dose of propofol used was 96.4 mg (range 40-200 mg). Younger patients required higher doses of propofol than older patients (20-40 years vs ≥ 61 years: 115.3 ± 32 mg vs 89.7 ± 21 mg, P < 0.001). Transient supplemental oxygen supply was needed by five patients (0.2%); no other complications occurred. The questionnaires were completed by 1820 (87%) of 2101 patients and most rated their overall satisfaction as excellent (80%) or good (17%). The majority (65%) of patients drove home or to their office after their colonoscopy. Most (99%) were willing to repeat the same procedure. No incidents occurred within 24 h after colonoscopy.

CONCLUSION: Propofol sedation using a dose < 200 mg proved both safe and practical for outpatient colonoscopy.

Keywords: Colonoscopy, Propofol, Colorectal cancer

INTRODUCTION

Colorectal cancer is one of the main causes of death from cancer in western countries and in Japan. There is no clear strategy for reducing the incidence of colorectal cancer, therefore, reduction in mortality relies on removal of premalignant lesions and detection of cancer at an early stage by colonoscopy[1,2]. In the face of increasing demands for gastroenterological services, the success of colonoscopic screening in the outpatient setting depends on patient acceptability[3]. CO2 insufflation and the water method for unsedated colonoscopy have been shown to be more acceptable than unsedated conventional colonoscopy[4,5]. We previously demonstrated that use of a small-caliber pediatric colonoscope resulted in completed colonoscopies in patients who had an unsuccessful procedure using a standard colonoscope[6]. The use of variable stiffness colonoscopes significantly reduced procedure-related pain and the dose of propofol required for sedation during colonoscopy[7].

Recently, the feasibility and safety of endoscopist-directed propofol administration was confirmed in a study of 646 080 cases from 28 centers[8]. Endoscopist-directed propofol sedation refers to administration of propofol by a non-anesthesia specialist under the direct supervision of the endoscopist performing the endoscopic procedure. Propofol sedation for colonoscopy was shown to be superior to other sedation methods in that propofol was associated with a low incidence of cardiopulmonary complications and was superior to benzodiazepines with regard to rapidity of both induction of sedation and recovery[9-11].

These results have been confirmed by meta-analysis[12]. We have previously reported that propofol sedation was both safe and practical for diagnostic esophagogastroduodenoscopy and endoscopic procedures in patients aged ≥ 90 years[13-16]. In addition, we have allowed our patients to drive home after colonoscopy, based on the experience with diagnostic esophagogastroduodenoscopy in our endoscopy unit[13,14]. Here, we report a prospective evaluation of the safety and effectiveness of propofol sedation with follow-up for 24 h after outpatient colonoscopy.

MATERIALS AND METHODS

Patients

The study was done at the Showa Inan General Hospital and included outpatients who underwent only colonoscopy. Emergency procedures were excluded. Patients were also excluded if they were < 20 years old, pregnant, assigned to American Society of Anesthesiologists (ASA) class III and IV, overweight (> 100 kg), or allergic to the drugs used or their components (soybeans or eggs). Routine standard monitoring at this unit included continuous assessment of peripheral oxygen saturation (SpO2) and heart rate. Clinical assessment of the patients included measurement of respiratory effort by visual assessment and by palpation of the chest wall and abdominal excursion and/or palpation of exhaled breath. When oxygen desaturation (SpO2 < 90%) continued for > 20 s, supplemental oxygen was given. The endoscopic team consisted of the nurse who administered the drugs and was responsible for the patient, the endoscopist, and a second nurse to assist the endoscopist and the patient-monitoring nurse.

Propofol was administered for endoscopic sedation by nurses supervised by endoscopists. Both the nurses and endoscopists had advanced cardiac life support certification, advanced airway training, didactic training on propofol, observation of cases, and supervised administration of propofol by anesthesiologists before beginning propofol administration supervised by the endoscopist. The training period typically lasted about 2 wk.

The study was conducted in accordance with the Helsinki Declaration and was approved by the ethics committee at the hospital. Verbal and written informed consent was obtained from all patients.

All colonoscopies were performed by six skilled endoscopists (Horiuchi A, Nakayama Y, Kajiyama M, Kato N, Kamijima T, Ichise Y) who each perform > 300 colonoscopies/year. All the procedures were conducted under propofol sedation (AstraZeneca, Osaka, Japan)[13,14]. The standard bowel preparation was a polyethylene glycol solution (Ajinomoto Pharmaceutical Co, Tokyo, Japan).

Study design

Colonoscopy was performed in the lateral decubitus position. A butterfly needle for the bolus injection of propofol was placed on the patient’s forearm shortly before the start of colonoscopy and was removed after completion of the procedure. Propofol was given by bolus injection with an age-adjusted standard protocol of 60 mg for patients aged < 70 years, 40 mg for patients aged 70-89 years, and 20 mg for those aged ≥ 90 years. Adequate sedation was considered achieved when the patients passed through the following sequence: eyes closing, one or two yawns, and cessation of body movements. The target level of sedation was moderate conscious sedation with the patients still being able to respond purposefully to verbal commands. When the target level was not obtained or the patients were undersedated, additional injections of 20 mg propofol were given up to a maximum of 200 mg.

A decline in SpO2 to < 90% that continued for > 20 s was regarded as respiratory depression associated with sedation. Vital signs were frequently assessed but not on a periodic basis. In addition to monitoring of vital signs, the patient’s condition was assessed more globally by visual inspection. Monitoring and complications were recorded by a registered nurse. SpO2 was routinely captured by visual inspection of the monitor and the value was recorded on the vital sign sheet.

After the procedure, patients were moved to a waiting room after they could stand by themselves and they were discharged after they were fully awake. Full recovery, including consciousness and psychomotor function was assessed using three criteria: (1) Level of consciousness (fully awake and responding to questions from the recovery room nurse); (2) Ability to stand on one-foot; and (3) Ability to walk in a straight line without instability for 5 m. These three criteria were assessed every 15 min starting 30 min after the procedure; full recovery was defined as meeting all three criteria. The nurses reconfirmed the absence of re-emerging sedative effects and finally permitted patients to leave the endoscopic unit.

In addition, we provided questionnaires. Within 2 wk after the procedure, patients were contacted by telephone and asked about overall satisfaction for this procedure, whether they drove home or to their office after colonoscopy, the occurrence of any accidents within 24 h after colonoscopy and their willingness to repeat the same procedure next time (yes/no).

Study parameters

The principal parameters were the occurrence of adverse events within 24 h after colonoscopy and overall satisfaction for the procedure. Secondary parameters included successful procedure, respiratory depression, and other complications. Respiratory depression was defined as the need of oxygen supply due to an oxygen desaturation (SpO2 < 90%) that continued more than 20 s.

Instruments

The Olympus PCF-Q260AI videoscope used has an insertion diameter of 11.3 mm, an accessory channel diameter of 2.8 mm, a total length of 1335 mm, and a working length of 1030 mm.

Statistical analysis

Data are presented as mean ± SD. The χ2 test, with Yates’ correction for continuity where appropriate, was used for comparison of categorical data. Fisher’s exact test was used when the numbers were small. For parametric data, Student’s t test was used when two means were compared. Analysis of variance was used when the three groups were compared and positive results were confirmed using Tukey’s Honestly Significantly Different procedure. A value of P < 0.05 was regarded as significant. Statistical analysis was performed by using JMP® 9.0.2 version software (SAS Institute Inc., Cary, NC, United States).

RESULTS

Between January 2010 and December 2010, 2101 consecutive patients received outpatient colonoscopy based on a standard protocol of age-adjusted doses of propofol (Table 1). All procedures were completed successfully. The patients’ ages ranged from 20 to 94 years. The most common indications for colonoscopy were: colorectal cancer screening in 785 (37%), hemopositive stools in 538 (26%), and abdominal symptoms in 406 (19%). Mean procedure time was 14 min (range, 8-46 min). A biopsy and/or polypectomy was performed in 775 patients (37%). Oxygen desaturation requiring supplemental oxygen (1-3 L/min) occurred in 0.2% (five patients); mask ventilation or endotracheal intubation was not required in any case. In no case did respiratory event or laryngospasm occur. No other complications occurred (Table 1). Full recovery within 60 min after the procedure was present in 100%.

Table 1.

Demographic and clinical data in 2101 patients who underwent colonoscopy using propofol sedation

n (%)
Sex: Male 1149 (55)
Mean age (range) (yr) 66 (20-94)
Mean body weight (range) (kg) 56.7 (32-98)
Indication
Screening 785 (37)
Hemopositive stool 538 (26)
Abdominal symptoms 406 (19)
Hematochezia 140 (7)
Surveillance 133 (6)
Anemia 70 (3)
Others 29 (1)
Propofol dose (mg):
About 40 110 (5)
60 239 (11)
80 623 (30)
100-120 973 (46)
140-160 131 (6)
180-200 25 (1)
Successful procedure 2101 (100)
Mean procedure time (range) (min) 14 (8-46)
Oxygen administered 5 (0.2)
Mask ventilation required 0 (0)
Heart rate < 50 beats/min 0 (0)
Complications 0 (0)
Full recovery 60 min after the procedure 2101 (100)

Values are numbers (percentages) of patients except for mean age, mean body weight, and mean procedure time.

The mean dose of propofol used was 96.4 mg (Table 2). There were no significant differences in the dose of propofol used between men and women (95.0 ± 26 mg vs 98.1 ± 25 mg, P = 0.18), however younger patients required higher doses of propofol than older patients (20-40 years vs ≥ 61 years, 115.3 ± 32 mg vs 89.7 ± 21 mg, P < 0.001). Of the 2101 patients, 495 (24%) had at least an adenoma detected. Fifty-two (3%) had invasive colorectal cancer. Colorectal adenomas with high-grade dysplasia were found in 32 (2%) patients. The detection rate of adenoma in this study was 53 adenomas/100 colonoscopies. Adenomas were distributed evenly in the colon and rectum.

Table 2.

Relationship between age or sex and dose of propofol used in 2101 patients who underwent colonoscopy

Age (yr) No. (M/F) Propofol dose (mg)
P value
Total (range) Male Female
20-401 150 (89/61) 115.3 ± 32 (40-200) 113.4 ± 27 118.2 ± 24 0.43
41-60 563 (316/247) 107.7 ± 27 (40-200) 106.9 ± 28 108.7 ± 25 0.19
≥ 61 1388 (744/644) 89.7 ± 21 (40-200) 87.7 ± 23 92.1 ± 19 0.32
Total 2101 (1149/952) 96.4 ± 27 95.0 ± 26 98.1 ± 25 0.18

Values are mean ± SD except for number of patients and range of dose used of propofol. P value shows the difference between male and female patients.

1

There were significant differences in the doses of propofol in each group between age 20-40 and ≥ 61 years (P < 0.001).

The questionnaires were completed by 1820 (87%) of 2101 patients (Table 3). Their mean age and mean body weight were 65 years and 58.7 kg. The majority rated their overall satisfaction for this procedure as excellent (80%) or good (17%). The majority (65%) of subjects drove home or to their office after their colonoscopy. No associated incidents within 24 h after colonoscopy occurred. Most (99%) were willing to repeat the same procedure.

Table 3.

Demographic data and results of questionnaires in 1820 patients who underwent colonoscopy using propofol sedation

Sex: Male 954 (52)
Mean age (range) (yr) 65 (33-80)
Mean body weight (range) (kg) 58.7 (45-98)
Did you find propofol sedation for your colonoscopy satisfactory?
Excellent 1456 (80%)
Good 309 (17%)
No 11 (0.6%)
NA 8 (2.4%)
Did you drive home or to the office after your colonoscopy?
Yes 1183 (65%)
No 637 (35%)
Did you experience any accidents within 24 h after your colonoscopy?
Yes 0 (0%)
No 1820 (100%)
Do you want to repeat the same procedure next time?
Yes 1805 (99%)
No 15 (1%)

Values are numbers (percentages) of patients except for mean age and mean body weight. NA: Not available.

DISCUSSION

This study describes the safety and outcomes of propofol sedation given to 2101 patients for outpatient colonoscopy. Previous studies have involved propofol dosages ranging from 60 to 300 mg using an indwelling catheter for endoscopic sedation[9-12,17-21]. In the present study, the mean dose of propofol used was 96.4 mg, which corresponded to that of a previous study in the Japanese population[17]. On the basis of our pervious experiences[13,14], the protocol adopted here focused on safety with the initial dose of 40 or 60 mg propofol designed to minimize hypoxemia during the procedure; only 0.2% required oxygen, which is less than previous studies[9-12]. No subject required mechanical ventilation during the procedures via either endotracheal intubation or a mask (Table 1). The routine use of supplemental oxygen during colonoscopy may mask respiratory depression[22], therefore, we chose to administer supplemental oxygen only when needed. No subjects experienced bradycardia (heart rate < 50 beats/min). Other studies with low-dose propofol have reported rates of bradycardia up to 10%[23]; the differences may relate to difference in the sedation method because studies with bradycardia have typically used a combination of propofol, midazolam and meperidine. All procedures were done with pediatric variable stiffness colonoscope, thus, it is impossible to assess whether the pediatric variable stiffness colonoscope, or the lower dose of propofol required, was responsible for the low incidence of cardiopulmonary depression.

Generally, patients are not permitted to drive themselves within the first day after endoscopic sedation. Riphaus et al[24] have reported that current recommendations that patients should be refrain from driving and unescorted use of public transport for 24 h after sedation may need to be reconsidered in patients who receive propofol sedation. Based on our previous study using a driving simulator showing that driving ability recovered to the basal level within 60 min of low-dose propofol sedation[13], patients have been permitted to drive themselves after colonoscopy as well as esophagogastroduodenoscopy at our endoscopy unit. In this study, the majority (65%) of patients drove home or to their office after their colonoscopy. No sedation-associated incidents within 24 h after colonoscopy occurred in the 1820 subjects responding.

Our recent study used a number connection test and a driving simulator test to assess psychomotor recovery before and 1 h and 2 h after colonoscopy[25]. Psychomotor recovery was evident as early as 1 h after propofol sedation. Additional studies are needed before it can be routinely recommended that patients be permitted to drive home after endoscopy using only propofol sedation. Effective endoscopic sedation depends on the type of procedure and the procedure time. In most patients, an appropriate level of sedation can be reached through the use of a benzodiazepine combined with a narcotic. In contrast, we gave propofol by bolus titration with an initial dose of 40-60 mg followed by dose of 20 mg beginning 30-60 s later. The appropriateness of additional bolus doses was determined by the level of sedation and the respiratory effect. When moderate conscious sedation was not obtained or the patients were undersedated, additional injections of 20 mg propofol were given up to a maximum of 200 mg; 180-200 mg were required in only 25 patients (1.2%). The advantages of propofol using a butterfly needle include immediate onset of action and fast recovery, which likely contributed to the high level of acceptability and cost-effectiveness for outpatient colonoscopy. In our facility, a butterfly needle has been used instead of an indwelling cannula for about 60 000 patients. Even if a patient in conscious sedation moves his/her arm, the butterfly needle is usually placed stably in the vein. This butterfly needle method is thought to be a safe and practical way to administer propofol over 15-30 min.

The average procedure time was 14 min and the detection rate of adenoma was 24% as the proportion of patients in whom at least one adenoma was identified in this study. The adenoma detection rate that was reported to be an independent predictor of the risk of interval colorectal cancer after screening colonoscopy was compatible to our data[26]. Therefore, this sedation method is likely an important variable in ensuring quality in colonoscopy.

Unsedated colonoscopy is still the main type of procedure in many countries. Even if sedation is safe, it requires an extra nurse and a team educated for monitoring, resulting in higher costs. The requirement for an escort and time burden of recovery from sedation are both barriers to the acceptance of screening colonoscopy. Improved acceptance of colonoscopy is important to allow full use of colonoscopy in cancer screening and prevention. Colonoscopy can be completed without sedation in the majority of patients and undoubtedly there is a place for unsedated colonoscopy, especially in areas where cost containment is a primary concern[27-29].

This study had some limitations. The sedation level was assessed using minimal, moderate, and deep sedation on the basis of the ASA level[30], but this was not recorded for each patient during the study. Although the patients may have had amnesia after propofol sedation, the questionnaire in this study did not include any questions related to amnesia. Blood pressure monitoring was not routinely performed in this study. Blood pressure monitoring is generally a standard practice whenever administering propofol in the United States but not in Japan. We were therefore unable to comment on episodes of hypotension in our series. The monitoring used (e.g., continuous assessment of SpO2 and heart rate) is the standard in Japan.

In conclusion, propofol sedation was associated with good acceptance of colonoscopy and willingness to repeat the procedure and enabled patients to drive home safely by themselves after colonoscopy. Propofol sedation using a dose < 200 mg was safe and practical. Increased use of this sedation method may improve the acceptability of colonoscopy, which may enable population wide screening and decrease colorectal cancer mortality.

ACKNOWLEDGMENTS

The authors thank David Y Graham for his English editorial assistance.

COMMENTS

Background

Despite the increasing usage of short-acting sedatives, the recommendations that patients should refrain from driving and the unescorted use of public transport for 24 h after sedation remain unchanged. The authors previously reported that recovery after low-dose propofol sedation for diagnostic esophagogastroduodenoscopy was such that the patients were able to drive home. In addition, the recent study using a number connection test and a driving simulator test demonstrated that psychomotor recovery was evident as early as 1 h after propofol sedation for outpatient colonoscopy.

Research frontiers

The authors report a prospective evaluation of the safety and effectiveness of propofol sedation with follow-up for 24 h after outpatient colonoscopy.

Innovations and breakthroughs

Propofol sedation was associated with good acceptance of colonoscopy and willingness to repeat the procedure and enabled patients to drive home safely by themselves after colonoscopy. Propofol sedation using a dose < 200 mg was safe and practical. Increased use of this sedation method may improve the acceptability of colonoscopy, which may enable population-wide screening and decrease colorectal cancer mortality.

Applications

The findings in this study indicate that patients sedated with propofol may be capable of safely driving 1 h after colonoscopy. The ability to drive home after sedation reduces the need for an accompanying individual and thus lowers the costs and burden associated with endoscopy.

Peer review

This is a well-written paper providing new data on safety of propofol sedation and new information about patients checking out and driving home after propofol sedation.

Footnotes

Peer reviewers: Andrew Ukleja, MD, Assistant Professor, Clinical Assistant Professor of Medicine, Director of Nutrition Support Team, Director of Esophageal Motility Laboratory, Department of Gastroenterology, Cleveland Clinic Florida, 2950 Cleveland Clinic Blvd., Weston, FL 33331, United States; Jukka-Pekka Mecklin, MD, PhD, Professor, Surgeon-in-Chief, Department of Surgery, Jyvaskyla Central Hospital, 40620 Jyvaskyla, Finland

S- Editor Cheng JX L- Editor Kerr C E- Editor Li JY

References

  • 1.Winawer SJ, Zauber AG, Ho MN, O’Brien MJ, Gottlieb LS, Sternberg SS, Waye JD, Schapiro M, Bond JH, Panish JF. Prevention of colorectal cancer by colonoscopic polypectomy. The National Polyp Study Workgroup. N Engl J Med. 1993;329:1977–1981. doi: 10.1056/NEJM199312303292701. [DOI] [PubMed] [Google Scholar]
  • 2.Winawer SJ, Fletcher RH, Miller L, Godlee F, Stolar MH, Mulrow CD, Woolf SH, Glick SN, Ganiats TG, Bond JH, et al. Colorectal cancer screening: clinical guidelines and rationale. Gastroenterology. 1997;112:594–642. doi: 10.1053/gast.1997.v112.agast970594. [DOI] [PubMed] [Google Scholar]
  • 3.Bjorkman DJ, Popp JW. Measuring the quality of endoscopy. Gastrointest Endosc. 2006;63:S1–S2. doi: 10.1016/j.gie.2006.02.022. [DOI] [PubMed] [Google Scholar]
  • 4.Uraoka T, Kato J, Kuriyama M, Hori K, Ishikawa S, Harada K, Takemoto K, Hiraoka S, Fujita H, Horii J, et al. CO(2) insufflation for potentially difficult colonoscopies: efficacy when used by less experienced colonoscopists. World J Gastroenterol. 2009;15:5186–5192. doi: 10.3748/wjg.15.5186. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Leung FW, Aharonian HS, Leung JW, Guth PH, Jackson G. Impact of a novel water method on scheduled unsedated colonoscopy in U.S. veterans. Gastrointest Endosc. 2009;69:546–550. doi: 10.1016/j.gie.2008.08.014. [DOI] [PubMed] [Google Scholar]
  • 6.Horiuchi A, Nakayama Y, Kajiyama M, Fujii H, Tanaka N. Usefulness of a small-caliber, variable-stiffness colonoscope as a backup in patients with difficult or incomplete colonoscopy. Am J Gastroenterol. 2004;99:1936–1940. doi: 10.1111/j.1572-0241.2004.40201.x. [DOI] [PubMed] [Google Scholar]
  • 7.Lee DW, Li AC, Ko CW, Chu DW, Chan KC, Poon CM, Sin KS, Leung KF, Sze TS, Chan AC, et al. Use of a variable-stiffness colonoscope decreases the dose of patient-controlled sedation during colonoscopy: a randomized comparison of 3 colonoscopes. Gastrointest Endosc. 2007;65:424–429. doi: 10.1016/j.gie.2006.08.027. [DOI] [PubMed] [Google Scholar]
  • 8.Rex DK, Deenadayalu VP, Eid E, Imperiale TF, Walker JA, Sandhu K, Clarke AC, Hillman LC, Horiuchi A, Cohen LB, et al. Endoscopist-directed administration of propofol: a worldwide safety experience. Gastroenterology. 2009;137:1229–1237; quiz 1229-1237. doi: 10.1053/j.gastro.2009.06.042. [DOI] [PubMed] [Google Scholar]
  • 9.Seifert H, Schmitt TH, Gültekin T, Caspary WF, Wehrmann T. Sedation with propofol plus midazolam versus propofol alone for interventional endoscopic procedures: a prospective, randomized study. Aliment Pharmacol Ther. 2000;14:1207–1214. doi: 10.1046/j.1365-2036.2000.00787.x. [DOI] [PubMed] [Google Scholar]
  • 10.Sipe BW, Rex DK, Latinovich D, Overley C, Kinser K, Bratcher L, Kareken D. Propofol versus midazolam/meperidine for outpatient colonoscopy: administration by nurses supervised by endoscopists. Gastrointest Endosc. 2002;55:815–825. doi: 10.1067/mge.2002.124636. [DOI] [PubMed] [Google Scholar]
  • 11.Ulmer BJ, Hansen JJ, Overley CA, Symms MR, Chadalawada V, Liangpunsakul S, Strahl E, Mendel AM, Rex DK. Propofol versus midazolam/fentanyl for outpatient colonoscopy: administration by nurses supervised by endoscopists. Clin Gastroenterol Hepatol. 2003;1:425–432. doi: 10.1016/s1542-3565(03)00226-x. [DOI] [PubMed] [Google Scholar]
  • 12.Qadeer MA, Vargo JJ, Khandwala F, Lopez R, Zuccaro G. Propofol versus traditional sedative agents for gastrointestinal endoscopy: a meta-analysis. Clin Gastroenterol Hepatol. 2005;3:1049–1056. doi: 10.1016/s1542-3565(05)00742-1. [DOI] [PubMed] [Google Scholar]
  • 13.Horiuchi A, Nakayama Y, Katsuyama Y, Ohmori S, Ichise Y, Tanaka N. Safety and driving ability following low-dose propofol sedation. Digestion. 2008;78:190–194. doi: 10.1159/000187118. [DOI] [PubMed] [Google Scholar]
  • 14.Horiuchi A, Nakayama Y, Hidaka N, Ichise Y, Kajiyama M, Tanaka N. Low-dose propofol sedation for diagnostic esophagogastroduodenoscopy: results in 10,662 adults. Am J Gastroenterol. 2009;104:1650–1655. doi: 10.1038/ajg.2009.250. [DOI] [PubMed] [Google Scholar]
  • 15.Horiuchi A, Nakayama Y, Tanaka N, Ichise Y, Katsuyama Y, Ohmori S. Propofol sedation for endoscopic procedures in patients 90 years of age and older. Digestion. 2008;78:20–23. doi: 10.1159/000151765. [DOI] [PubMed] [Google Scholar]
  • 16.Horiuchi A, Nakayama Y, Kajiyama M, Tanaka N. Effectiveness of outpatient percutaneous endoscopic gastrostomy replacement using esophagogastroduodenoscopy and propofol sedation. World J Gastrointest Endosc. 2012;4:45–49. doi: 10.4253/wjge.v4.i2.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 17.Tohda G, Higashi S, Wakahara S, Morikawa M, Sakumoto H, Kane T. Propofol sedation during endoscopic procedures: safe and effective administration by registered nurses supervised by endoscopists. Endoscopy. 2006;38:360–367. doi: 10.1055/s-2005-921192. [DOI] [PubMed] [Google Scholar]
  • 18.Rex DK, Overley C, Kinser K, Coates M, Lee A, Goodwine BW, Strahl E, Lemler S, Sipe B, Rahmani E, et al. Safety of propofol administered by registered nurses with gastroenterologist supervision in 2000 endoscopic cases. Am J Gastroenterol. 2002;97:1159–1163. doi: 10.1111/j.1572-0241.2002.05683.x. [DOI] [PubMed] [Google Scholar]
  • 19.Walker JA, McIntyre RD, Schleinitz PF, Jacobson KN, Haulk AA, Adesman P, Tolleson S, Parent R, Donnelly R, Rex DK. Nurse-administered propofol sedation without anesthesia specialists in 9152 endoscopic cases in an ambulatory surgery center. Am J Gastroenterol. 2003;98:1744–1750. doi: 10.1111/j.1572-0241.2003.07605.x. [DOI] [PubMed] [Google Scholar]
  • 20.Sipe BW, Scheidler M, Baluyut A, Wright B. A prospective safety study of a low-dose propofol sedation protocol for colonoscopy. Clin Gastroenterol Hepatol. 2007;5:563–566. doi: 10.1016/j.cgh.2007.01.013. [DOI] [PubMed] [Google Scholar]
  • 21.Repici A, Pagano N, Hassan C, Carlino A, Rando G, Strangio G, Romeo F, Zullo A, Ferrara E, Vitetta E, et al. Balanced propofol sedation administered by nonanesthesiologists: The first Italian experience. World J Gastroenterol. 2011;17:3818–3823. doi: 10.3748/wjg.v17.i33.3818. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 22.Sharma VK, Nguyen CC, Crowell MD, Lieberman DA, de Garmo P, Fleischer DE. A national study of cardiopulmonary unplanned events after GI endoscopy. Gastrointest Endosc. 2007;66:27–34. doi: 10.1016/j.gie.2006.12.040. [DOI] [PubMed] [Google Scholar]
  • 23.Cohen LB, Dubovsky AN, Aisenberg J, Miller KM. Propofol for endoscopic sedation: A protocol for safe and effective administration by the gastroenterologist. Gastrointest Endosc. 2003;58:725–732. doi: 10.1016/s0016-5107(03)02010-8. [DOI] [PubMed] [Google Scholar]
  • 24.Riphaus A, Gstettenbauer T, Frenz MB, Wehrmann T. Quality of psychomotor recovery after propofol sedation for routine endoscopy: a randomized and controlled study. Endoscopy. 2006;38:677–683. doi: 10.1055/s-2006-925244. [DOI] [PubMed] [Google Scholar]
  • 25.Horiuchi A, Nakayama Y, Fujii H, Katsuyama Y, Ohmori S, Tanaka N. Psychomotor recovery and blood propofol level in colonoscopy when using propofol sedation. Gastrointest Endosc. 2012;75:506–512. doi: 10.1016/j.gie.2011.08.020. [DOI] [PubMed] [Google Scholar]
  • 26.Kaminski MF, Regula J, Kraszewska E, Polkowski M, Wojciechowska U, Didkowska J, Zwierko M, Rupinski M, Nowacki MP, Butruk E. Quality indicators for colonoscopy and the risk of interval cancer. N Engl J Med. 2010;362:1795–1803. doi: 10.1056/NEJMoa0907667. [DOI] [PubMed] [Google Scholar]
  • 27.Leung FW, Aljebreen AM, Brocchi E, Chang EB, Liao WC, Mizukami T, Schapiro M, Triantafyllou K. Sedation-risk-free colonoscopy for minimizing the burden of colorectal cancer screening. World J Gastrointest Endosc. 2010;2:81–89. doi: 10.4253/wjge.v2.i3.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 28.Leung FW. Is there a place for sedationless colonoscopy? J Interv Gastroenterol. 2011;1:19–22. doi: 10.4161/jig.1.1.14592. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 29.Paggi S, Radaelli F, Amato A, Meucci G, Spinzi G, Rondonotti E, Terruzzi V. Unsedated colonoscopy: an option for some but not for all. Gastrointest Endosc. 2012;75:392–398. doi: 10.1016/j.gie.2011.09.015. [DOI] [PubMed] [Google Scholar]
  • 30.Cohen LB, Hightower CD, Wood DA, Miller KM, Aisenberg J. Moderate level sedation during endoscopy: a prospective study using low-dose propofol, meperidine/fentanyl, and midazolam. Gastrointest Endosc. 2004;59:795–803. doi: 10.1016/s0016-5107(04)00349-9. [DOI] [PubMed] [Google Scholar]

Articles from World Journal of Gastroenterology : WJG are provided here courtesy of Baishideng Publishing Group Inc

RESOURCES