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American Journal of Human Genetics logoLink to American Journal of Human Genetics
. 2012 Jul 13;91(1):209. doi: 10.1016/j.ajhg.2012.06.001

Whole-Exome Sequencing Identifies Mutations in GPR179 Leading to Autosomal-Recessive Complete Congenital Stationary Night Blindness

Isabelle Audo, Kinga Bujakowska, Elise Orhan, Charlotte M Poloschek, Sabine Defoort-Dhellemmes, Isabelle Drumare, Susanne Kohl, Tien D Luu, Odile Lecompte, Eberhart Zrenner, Marie-Elise Lancelot, Aline Antonio, Aurore Germain, Christelle Michiels, Claire Audier, Mélanie Letexier, Jean-Paul Saraiva, Bart P Leroy, Francis L Munier, Saddek Mohand-Saïd, Birgit Lorenz, Christoph Friedburg, Markus Preising, Ulrich Kellner, Agnes B Renner, Veselina Moskova-Doumanova, Wolfgang Berger, Bernd Wissinger, Christian P Hamel, Daniel F Schorderet, Elfride De Baere, Dror Sharon, Eyal Banin, Samuel G Jacobson, Dominique Bonneau, Xavier Zanlonghi, Guylene Le Meur, Ingele Casteels, Robert Koenekoop, Vernon W Long, Francoise Meire, Katrina Prescott, Thomy de Ravel, Ian Simmons, Hoan Nguyen, Hélène Dollfus, Olivier Poch, Thierry Léveillard, Kim Nguyen-Ba-Charvet, José-Alain Sahel, Shomi S Bhattacharya, Christina Zeitz
PMCID: PMC3397255

(The American Journal of Human Genetics 90, 321–330; February 10, 2012)

In the original version of this report, which describes GPR179 mutations in patients with complete congenital stationary night blindness, we applied an antibody against human GPR179 to mouse retinal sections and concluded that GPR179 was localized to horizontal cells and Müller cell endfeet (Figure 4). We have since discovered that this use of the antibody does not result in specific labeling. Our recent results support the conclusion of the parallel study of Peachey et al.,1 which concluded that GPR179 is expressed in retinal bipolar cells.

Reference

  • 1.Peachey N.S., Ray T.A., Florijn R., Rowe L.B., Sjoerdsma T., Contreras-Alcantara S., Baba K., Tosini G., Pozdeyev N., Iuvone P.M. GPR179 is required for depolarizing bipolar cell function and is mutated in autosomal-recessive complete congenital stationary night blindness. Am. J. Hum. Genet. 2012;90:331–339. doi: 10.1016/j.ajhg.2011.12.006. [DOI] [PMC free article] [PubMed] [Google Scholar]

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