Table 2.
Multivariable analysis for outcome according to the miR-3151 expression status in older patients with CN-AML
| End point | Variables in final models | OR/HR | 95% CI | P |
|---|---|---|---|---|
| CR* | miR-3151, high vs low | 0.56 | 0.27-1.19 | .13 |
| BAALC, high vs low | 0.23 | 0.10-0.52 | < .001 | |
| WBC, continuous, 50-unit increase | 0.65 | 0.48-0.88 | .01 | |
| DFS† | miR-3151, high vs low | 2.38 | 1.47-3.85 | < .001 |
| FLT3-TKD, positive vs no TKD | 0.28 | 0.11-0.73 | .009 | |
| ERG, high vs low | 2.41 | 1.50-3.86 | < .001 | |
| OS‡ | miR-3151, high vs low | 1.69 | 1.14-2.50 | .009 |
| ERG, high vs low | 1.71 | 1.16-2.53 | .007 | |
| DNMT3A | ||||
| R882 v wild-type | 1.66 | 1.04-2.66 | .04 | |
| Non-R882 vs wild-type | 1.11 | 0.61-2.01 | .74 | |
| BAALC, high vs low | 1.93 | 1.32-2.82 | < .001 |
CR indicates complete remission; OR, odds ratio; HR, hazard ratio; OS, overall survival; DFS, disease-free survival; OR > 1.0, a higher CR rate for the higher values of the continuous variables and the first category listed for the categorical variables; OR < 1.0, a lower CR rate for the higher values of the continuous variables and the first category listed for the categorical variables; HR > 1.0, a higher risk for an event for the first category listed for the categorical variables; HR < 1.0, a lower risk for an event for the first category listed for the categorical variables; and 95% CI, 95% confidence interval..
Variables considered in the model based on univariable analyses were: miR-3151 expression (high vs low; median cut), BAALC expression (high vs low; median cut), ERG expression (high vs low; median cut), FLT3-ITD (positive vs no ITD), NPM1 (mutated vs wild-type), WT1 (mutated vs wild-type), MLL-PTD (present vs absent), ASXL1 (mutated vs wild-type), RUNX1 (mutated vs wild-type), WBC (continuous, 50-unit increase), platelets (continuous, 50-unit increase), and age (continuous, 10-year increase).
Variables considered in the model based on univariable analyses were: miR-3151 expression (high vs low; median cut), BAALC expression (high vs low; median cut), ERG expression (high vs low; median cut), FLT3-ITD (positive vs no ITD), FLT3-TKD (positive vs no TKD), NPM1 (mutated vs wild-type), DNMT3A (R882 vs Non-R882 vs wild-type), RUNX1 (mutated vs wild-type), WT1 (mutated vs wild-type), and WBC (continuous, 50-unit increase).
Variables considered in the model based on univariable analyses were: miR-3151 expression (high vs low; median cut), BAALC expression (high vs low; median cut), ERG expression (high vs low; median cut), FLT3-ITD (positive vs no ITD), NPM1 (mutated vs wild-type), ASXL1 (mutated vs wild-type), RUNX1 (mutated vs wild-type), WT1 (mutated vs wild-type), DNMT3A (R882 vs non-R882 vs wild-type), platelets (continuous, 50-unit increase), and WBC (continuous, 50-unit increase).