Figure 1.

A schematic representation of the suggested role for leptin in murine asthma, based upon the work by Shore et al. [21]. Although these findings were not entirely reproduced in a human interventional study of mild atopic asthma [37], epidemiologic evidence suggests that greater serum leptin concentrations are associated with more severe asthma, particularly among prepubertal boys and peripubertal/postpubertal girls [31, 32].