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. 1987 Dec 23;15(24):10083–10086. doi: 10.1093/nar/15.24.10083

Genes of nuclear encoded mitochondrial proteins: evidence for a variant of the 3' splice-site consensus sequence.

N Juretić 1, R Jaussi 1, U Mattes 1, P Christen 1
PMCID: PMC339931  PMID: 2827115

Abstract

The introns of animal nuclear genes and of viral genes encoding protein possess at their 3' splice-site the consensus sequence (CT)11NTCAG (Mount, S.M. (1982) Nucl. Acids Res. 10, 459-472; Green, M.R. (1986) Ann. Rev. Genet. 20, 671-708). However, the total 39 introns of the 5 imported mitochondrial proteins of higher eucaryotes whose gene structure has been determined to date show a predominance of 44% for base T at position -4. Apparently, a variant consensus sequence, i.e. (CT)11TTCAG, characterizes the genes of nuclear encoded mitochondrial proteins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown J. W. A catalogue of splice junction and putative branch point sequences from plant introns. Nucleic Acids Res. 1986 Dec 22;14(24):9549–9559. doi: 10.1093/nar/14.24.9549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Gellissen G., Bradfield J. Y., White B. N., Wyatt G. R. Mitochondrial DNA sequences in the nuclear genome of a locust. Nature. 1983 Feb 17;301(5901):631–634. doi: 10.1038/301631a0. [DOI] [PubMed] [Google Scholar]
  3. Green M. R. Pre-mRNA splicing. Annu Rev Genet. 1986;20:671–708. doi: 10.1146/annurev.ge.20.120186.003323. [DOI] [PubMed] [Google Scholar]
  4. Jaussi R., Cotton B., Juretić N., Christen P., Schümperli D. The primary structure of the precursor of chicken mitochondrial aspartate aminotransferase. Cloning and sequence analysis of cDNA. J Biol Chem. 1985 Dec 25;260(30):16060–16063. [PubMed] [Google Scholar]
  5. Korb H., Neupert W. Biogenesis of cytochrome c in Neurospora crassa. Synthesis of apocytochrome c, transfer to mitochondria and conversion to Holocytochrome c. Eur J Biochem. 1978 Nov 15;91(2):609–620. doi: 10.1111/j.1432-1033.1978.tb12714.x. [DOI] [PubMed] [Google Scholar]
  6. Maguire D. J., Day A. R., Borthwick I. A., Srivastava G., Wigley P. L., May B. K., Elliott W. H. Nucleotide sequence of the chicken 5-aminolevulinate synthase gene. Nucleic Acids Res. 1986 Feb 11;14(3):1379–1391. doi: 10.1093/nar/14.3.1379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Mount S. M. A catalogue of splice junction sequences. Nucleic Acids Res. 1982 Jan 22;10(2):459–472. doi: 10.1093/nar/10.2.459. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Nomiyama H., Fukuda M., Wakasugi S., Tsuzuki T., Shimada K. Molecular structures of mitochondrial-DNA-like sequences in human nuclear DNA. Nucleic Acids Res. 1985 Mar 11;13(5):1649–1658. doi: 10.1093/nar/13.5.1649. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Nyunoya H., Broglie K. E., Widgren E. E., Lusty C. J. Characterization and derivation of the gene coding for mitochondrial carbamyl phosphate synthetase I of rat. J Biol Chem. 1985 Aug 5;260(16):9346–9356. [PubMed] [Google Scholar]
  10. Scarpulla R. C., Agne K. M., Wu R. Isolation and structure of a rat cytochrome c gene. J Biol Chem. 1981 Jun 25;256(12):6480–6486. [PubMed] [Google Scholar]

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