Summary data showing changes in fasting plasma glucose (left), HOMA-IR (middle), and serum potassium (K), after 12 weeks of chlorthalidone (Chlor) alone (solid bars), chlorthalidone plus spironolactone (Spiro, hatched bars), and chlorthalidone plus irbesartan (gray bars) compared with baseline (white bars). Data are mean ± SE. * p < 0.01 vs baseline, † p < 0.05 vs chlorthalidone plus spironolactone, ‡ p < 0.01 vs chlorthalidone plus spironolactone.