Table 1.

Variables	Normal Range	Baseline	Chlorthalidone alone	Chlorthalidone plus Spironolactone	Chlorthalidone plus Irbesartan	ANOVA p
Age, years	50.6±2.3
BMI, kg/m²	30.1 ± 1.9
Female, %	35%
African Americans, %	35%
24-hr SBP, mmHg	< 130	135.2±2.6	123.8±2.1^*	120.9±2.4^*	120.6±2.4^*	0.001
24-hr DBP, mmHg	< 80	83.5±2.1	77.6±2.1^†	75.3±2.0^*	74.9±2.1^*	0.003
24-hr HR, beats/min	60–100	75±2	76±2	76±2	80±2	NS
Day SBP, mmHg	< 135	138.5±2.3	126.5±2.5^*	124.9±2.9^*	124.1±2.7^*	0.002
Day DBP, mmHg	< 85	86.6±2.1	79.9±1.7^*	78.1±1.5^*	76.8±1.9^*	0.004
Day HR, beats/min	60–100	77±2	77±2	78±2	81±2	NS
Night SBP, mmHg	< 120	131.1±2.6	119.7±2.1^*	117.2±2.4^*	114.1±2.4^*	0.0003
Night DBP, mmHg	< 80	79.5±2.1	74.1±2.1^†	71.7±2.0^*	68.7±2.1^*	0.0007
Night HR, beats/min	60–100	70±2	71±2	71±3	75±2^†	0.049
Casual SBP, mmHg	< 140	149.5±4.2	131.7± 2.3^*	132.9± 2.1^*	128.9± 3.2^*	< 0.0001
Casual DBP, mmHg	< 90	88.0±2.1	80.9±1.3^*	81.3±2.1^*	80.5±1.8^*	0.0014
Casual HR, beats/min	60–100	64±2	64±2	70±2	71±2	NS
PRA, ng/ml/hr	0.05–3.3	0.44	3.27^*	5.01^*	13.62^*^§	<0.0001
interquartile range		0.05–1.16	0.84–7.93	2.39–11.50	5.73–17.67
Aldosterone (ng/dL)	< 21	5.3±1.5	9.2±1.4^*	10.8±2.2^*	13.3±5.1^*	0.013
Insulin, mU/L, median	< 12	3.9	7.6^*	4.87^‡	6.8	0.024
interquartile range		3.00–6.05	4.08–19.7	3.50–6.78	3.28–10.25
QUICKI	> 0.31	0.40±0.02	0.35±0.01^*	0.39±0.02^‡	0.37±0.01	0.023

p < 0.01 vs baseline

^†

p < 0.05 vs baseline

^‡

p = 0.02 vs chlorthalidone alone

^§

p < 0.01 vs chlorthalidone alone