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. 1987 Feb 11;15(3):1165–1172. doi: 10.1093/nar/15.3.1165

Shufflon: multi-inversion of four contiguous DNA segments of plasmid R64 creates seven different open reading frames.

T Komano, A Kubo, T Nisioka
PMCID: PMC340515  PMID: 3029698

Abstract

The IncI alpha plasmid R64 was found to bear a highly mobile DNA segment which was designated as a clustered inversion region (J. Bacteriol. 165, 94-100, 1986). The clustered inversion region consists of four DNA segments designated respectively as A, B, C and D which differ in molecular size and restriction sites. The four DNA segments invert independently or in groups resulting in a complex DNA rearrangement. We now show the nucleotide sequence of the clustered inversion region of R64. The present results suggest that the clustered inversion region is a biological switch to select one of seven open reading frames whose primary structures at the region proximal to N-termini are constant while those at the C-terminal region are variable. A name, "Shufflon" was proposed to call this kind of the clustered inversion region.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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