Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Kinetic parameters of wild-type and mutant AChRs expressed in HEK cells
Abbreviations: AChR = acetylcholine receptor; HEK = human embryonic kidney fibroblast.
Rate constants ± SD are in units s−1, except for k+1, k+2, and k+b, which are μM−1s−1. K1= k−1/k+1, K2= k−2/k+2, KB = k−b/k+b, and θ = β/α. The values of k+1 and k−1 for the mutant receptor are constrained to that of wild type with the assumption that the 2 binding sites are independent.
