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. 1987 Feb 25;15(4):1745–1752. doi: 10.1093/nar/15.4.1745

Catalytic activity of the nucleic acid component of the 1,4-alpha-glucan branching enzyme from rabbit muscles.

T A Shvedova, G A Korneeva, V A Otroshchenko, T V Venkstern
PMCID: PMC340578  PMID: 2434932

Abstract

2.5 S RNA, the nucleic acid component of the 1,4-alpha-D-glucan: 1,4-alpha-D-glucan 6-alpha-(1,4-alpha-glucano)-transferase from rabbit muscles, devoid of any protein, catalyses the branching reaction, as does the holoenzyme. The conclusion is drawn that 2.5 S RNA is a ribozyme. To get an insight into the significance of different parts of the molecule for the catalytic activity of 2.5 S RNA, a large fragment isolated from its partial RNAase A digest was investigated. This fragment which proved to be the middle part of polyribonucleotide chain containing all modified nucleotides exerts some catalytic activity, too.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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