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. 1987 Feb 25;15(4):1807–1818. doi: 10.1093/nar/15.4.1807

A model study directed towards the preparation of nucleopeptides via H-phosphonate intermediates.

E Kuyl-Yeheskiely, C M Tromp, A H Schaeffer, G A van der Marel, J H van Boom
PMCID: PMC340583  PMID: 3103103

Abstract

The monofunctional phosphitylating reagents bis-(N,N-diethylamino)chlorophosphine and salicylchlorophosphine have been applied for the preparation of H-phosphonates of the amino acids serine, threonine and tyrosine. Experimental evidence showed that the latter reagent was less effective for the synthesis of a tyrosine H-phosphonate. The amino acids (peptide) H-phosphonates of serine or threonine proved to be suitable starting compounds for the formation of a phosphate diester bond with the 5'-OH of a d-nucleoside derivative using pivaloyl chloride as the activating reagent.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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