Table 2.

Descriptive analysis of the neurocognitive data

	Rifampicin/Placebo- Placebo	Placebo- Ketamine	Rifampicin- Ketamine
Neurocognitive Index ¶
0 min	105.6 ± 1.9	104.3 ± 4.1	104.6 ± 2.4
120 min	104.3 ± 4.1	77.6 ± 4.1*§	83.8 ± 11.3*§
300 min	104.6 ± 2.4§	101.0 ± 2.4§	98.1 ± 2.7§
Memory ¶
0 min	101.3 ± 5.2	104.7 ± 5.0	106.6 ± 4.5
120 min	88.9 ± 6.1	55.5 ± 5.7*	65.1 ± 4.7*
300 min	90.7 ± 5.3§	96.1 ± 4.1§	93.8 ± 5.5§
Psychomotor Speed ¶
0 min	108.2 ± 5.2	108.7 ± 4.8	107.8 ± 5.8
120 min	112.6 ± 7.0	86.8 ± 5.2*§	90.6 ± 3.9*§
300 min	117.0 ± 5.8§	113.9 ± 5.2§	114.8 ± 5.9§
Reaction Time ¶
0 min	97.4 ± 3.8	95.9 ± 5.3	90.9 ± 4.4
120 min	88.6 ± 3.6	78.8 ± 4.8*§	83.8 ± 4.8*§
300 min	91.5 ± 4.2	93.1 ± 3.6	88.6 ± 2.6
Complex Attention ¶
0 min	104.0 ± 4.4	99.4 ± 4.3	102.9 ± 3.3
120 min	97.2 ± 3.7	77.3 ± 7.5*§	85.8 ± 5.4*§
300 min	91.3 ± 2.9§	94.4 ± 7.5§	88.2 ± 4.1§
Cognitive Flexibility ¶
0 min	116.3 ± 3.2	112.6 ± 4.5	114.8 ± 3.3
120 min	110.1 ± 4.0	89.5 ± 7.3*§	94.2 ± 6.3*§
300 min	106.4 ± 4.0§	107.6 ± 10.9§	104.8 ± 3.7§

Values are mean ± SEM;

^¶Significant main treatment, time and time×treatment effects at P < 0.05.

Post-hoc analysis:

^*Treatment: P < 0.01 versus Rifampicin/Placebo-Placebo (at 120 min);

^§Time: P < 0.05 versus t = 0.