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Determination of the pharmacokinetic properties of GDXa and FXa in plasma. Normal plasma was spiked with 50 nM FXa (A) or GDXa (B), and incubated at 37°C. Aliquots were removed at different times and immediately diluted 25 times in buffer A for determination of residual activity. Half-lives were 1.4±0.1 min for FXa and 1.8±0.1 min for GDXa. Data are the mean of two different experiments.
