Table III.
Inhalation | Instillation | |||||
---|---|---|---|---|---|---|
Control | Printex 90 41.7 mg/m3 ∼ 287 mg/animal | Control | Printex 90 11 mg/animal | Printex 90 54 mg/animal | Printex 90 268 mg/animal | |
Females 3–5 days after exposure | ||||||
BAL | 0.55 ± 0.06 | 0.70 ± 0.10 | 0.90 ± 0.04 | 0.91 ± 0.09 | 0.78 ± 0.07 | 0.72 ± 0.07 |
Liver | 2.57 ± 0.19 | 3.25 ± 0.21* | 0.66 ± 0.06 | 0.55 ± 0.07 | 0.57 ± 0.07 | 0.52 ± 0.07 |
Dams at weaning 24–27 days after exposure | ||||||
BAL | 0.58 ± 0.05 | 0.60 ± 0.04 | 0.62 ± 0.02 | 0.69 ± 0.06 | 0.58 ± 0.01 | 0.50 ± 0.03** |
Liver | 1.24 ± 0.07 | 1.94 ± 0.11*** | 0.52 ± 0.05 | 0.55 ± 0.09 | 0.48 ± 0.02 | 0.58 ± 0.04 |
Offspring | ||||||
Liver newborns PND 2 | 3.50 ± 0.28 | 3.64 ± 0.37 | 0.66 ± 0.02 | 0.65 ± 0.03 | 0.73 ± 0.02 | 0.64 ± 0.03 |
Liver offspring at weaning PND 22–23 | 1.13 ± 0.09 | 1.56 ± 0.08*** | 0.39 ± 0.03 | 0.41 ± 0.04 | 0.42 ± 0.04 | 0.42 ± 0.03 |
Liver adolescents PND 50 (47) | 1.10 ± 0.16 | 1.69 ± 0.14** | 0.54 ± 0.04 | 0.48 ± 0.04 | 0.47 ± 0.04 | 0.52 ± 0.03 |
BAL, bronchoalveolar lavage; PND, post natal day (days after birth). Data are presented as mean number of lesions per 106 base pairs ± SEM (calculated from %DNA results). Offspring data are calculated as litter average, when sibling liver tissues were analyzed at the same collection point.
p < 0.05,
p < 0.01,
p < 0.001.