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. 2012 Jun 1;55(9):2501–2512. doi: 10.1007/s00125-012-2590-5

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© The Author(s) 2012

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Fig. 1 — Circulating EPC levels are reduced in type 2 diabetes. (a) Representative FACS plots and gating profile set on the basis of the isotype control sample as used for the quantification of CD34⁺ cells and CD34⁺KDR⁺ cells. (b) CD34⁺ cell levels were 1.3-fold lower in type 2 diabetic patients compared with healthy controls. (c) In patients with type 2 diabetes, similar levels of circulating CD34⁺ cells were observed in patients with and without MVD. (d) In non-diabetic individuals with MVD the total number of CD34⁺ cells was similar to that in healthy controls. (e) CD34⁺KDR⁺ cell levels were 1.7-fold lower in type 2 diabetic patients compared with healthy controls. (f) In type 2 diabetes, similar levels of circulating CD34⁺KDR⁺ cells were observed in patients with and without MVD. (g) In non-diabetic individuals with MVD the number of CD34⁺KDR⁺ cells was significantly reduced compared with healthy controls. Data are expressed as mean values ± SEM; *p < 0.05. T2DM, type 2 diabetes mellitus