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. 2012 Jul 16;1(7):e22. doi: 10.1038/oncsis.2012.22

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Copyright © 2012 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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PEA-15-AA has a strong antitumor effect in an ovarian cancer xenograft model. (a) Upper panel, incidence of tumor formation. Lower panel, tumor weights were significantly smaller with PEA-15-AA than with vector and PEA-15-DD. (b) Representative images showed tumor formation of SKOV3.ip1-vector, SKOV3.ip1-PEA-15-AA and SKOV3.ip1-PEA-15-DD cells in mouse peritoneal area. White arrows indicate tumors. (c) Immunohistochemical staining of HA, β-catenin and Ki-67 in tumor samples from the xenograft model. H&E, hematoxylin-eosin. Scale bars: 50 μm. Statistical significance was evaluated by paired t-test using GraphPad Prism software.